| Objective:To explore the application of Xianlinggubao capsule, Caltrate D600Fosamax tablet, a combination of three drugs in the treatment of primary osteoporosisclinical efficacy and safety.Method:Two affiliated hospital outpatient and inpatient department was diagnosedwith primary osteoporosis patients84cases, were randomly divided into treatmentgroup and control group with42cases in each group, two groups were taking calcium,D600,1/day.The control group plus Fosamax70mg/week, once/week; thetreatment group in the control group treated with clothing Xianlinggubao capsule,6/day, taking three hours, a course of6months.After12months of treatment wereobserved in two groups.Results:1)ã€The two group12months after clinical results: treatment group total effectivenessis92.86%, the total efficiency of76.19%for the control group, treatment group isobviously better than the control group.2)〠treatment for6months and12months after the measurement of the bone densitychanges:6months after the treatment, the treatment group and the control group,difference is not obvious (P>0.05); after12months of treatment difference isobvious (P <0.05), the treatment group than in the control group can increase bonedensity, and increased with the prolongation of treatment time in treatment group isbetter.3)〠in two groups before treatment,serum alkaline phosphatase was nodifferences(p>0.05);12months after treatment between the two groups hadsignifcant difference (p<0.05),the treatment group decreased more obviously.4)〠in two groups before treatment,serum alkaline phosphatase was nodifferences(p>0.05);12months after treatment between the two groups hadsignifcant difference (p<0.05), the treatment group inproved more obviously..5)ã€Group therapy in addition to2people with constipation and treated symptomatic improvement, the remaining two has no obvious adverse reaction (P>0.05).Conclusion: In medicine (Gail, D600, Fosamax) based on treatment combined withtraditional Chinese medicine (Xianlinggubao capsule) to the treatment of primaryosteoporosis is more superiority, is worthy of popularization in clinical treatment. |