The Relationship Between Vaspin And Type2Diabetes

Objective: To compare whether plasma vaspin were altered indifferent glucose tolerance individuals and to investigate the effects ofLiraglutide on the plasma vaspin levels in patients with T2DM.Methods:1. Plasma vaspin levels were measured by an ELISA in allthe patients include normal controls、IGT and T2DM. The relationshipbetween cycle vaspin levels、somatology and other biochemical indicatorswere also analyzed.2. Keep Liraglutide treatment for16weeks, andmeasure the plasma vaspin levels before and after treatment in T2DMpatients.Results:1.The plasma vaspin levels were higher in type2diabetesgroup compared with IGT (1.30±0.72vs.0.43±0.21ng/mL,P<0.05) andNGT group(1.30±0.72vs.0.54±0.22ng/mL, P<0.05).2. The plasma vaspinlevels in T2DM patients were positively related to FFA（r=0.394, P<0.05）,HbA1c（r=0.586, P<0.05）, FBG（r=0.626, P<0.05）,2hPBG（r=0.607,P<0.05and negatively related to HOMA-IR（r=-0.473, P<0.05）, HOMA-IS（r=-0.583, P<0.05）.3.2hPBG was an independent correlative factor ofthe plasma vaspin levels in T2DM patients （B=0.091, beta=0.682,P<0.01）.4. After Liraglutide treatment, BMI, WHR, HbA1c, FBG and2hPBG were significantly decreased (P<0.01), and the plasma vaspin levelswere significantly increased(0.92±0.38vs.0.73±0.32μg/L, P<0.05).after being treated by Liraglutide, HOMA-IS was also significantlyincreased(P<0.01) in T2DM.Conclusion:1. Plasma vaspin level changes was closely related toglycolipid metabolism and insulin resistance.2.Liraglutide can remarkablyincrease the plasma vaspin level and improve glucose metabolism andinsulin sensitivity of T2DM patients.