Comorbid Anxierty Symptoms Have Effect On The Treatment Of Depression

ObjectiveView the clinical feature and curative effect in the treatment of depression with anxiety symptom.or not.Research design and method319depression disorder patients received8weeks open anti-depression treatment., They were divided into2groups according to the HAMA:the group A is depression without anxiety (HAMA<14; n=134) and the goup B is depression comorbidity anxiety (HAMA≥14;n=185), the hamilton depressive scale (HAMD17)、the hamilton anxiety scale (HAMA)and the treatment emergent symptom scale(TESS) were used to evaluate the efficacy and sideeffect before the treatment and the1、2、4and8week.Result1. The risk of suicide between the group A and B is significant different (P<0.01).2. The baseline mean scores of HAMD and HAMA have significantly deference between the two groups (P<0.01), after8weeks treatment,The HAMD score of both groups decreased significantly compared with those before treatment(P<0.01);the group of depression without anxiety have121patients complete the8weeks treatment, the effective power is65.3%(n=79), and the goup of depression comorbidity anxiety have160patients to complete,the effective power is47.5%(n=76)(P<0.01), At week2,the onset rate of group A is75.2%(n=91), and group B is50.0%(n=80)(P<0.01). there have significantly deference in the mean scores of HAMD and HAMA on each time of the evaluation between the two groups(P<0.01).The onset rate at week2and the efficient rate as well as the clinical cure rate at week8, there have no significantly deference between the group A1(depression without anxiety symptoms and treatment with Escitalopram) and A2(depression without anxiety symptoms and treatment with venlafaxine)(P>0.05), the onset rate at week2and the efficient rate at week8are no difference between the group B1(depression with anxiety symptoms and treat with Escitalopram)and B2(depression with anxiety symptoms and treat with Venlafaxine)(P>0.05),but have significantly deference in the clinical cure rate at week8between the group B1and B2(P<0.05).3. The rate is3.7%and12.8%.The group of A1/A2and B1/B2show no significant difference in the scores of TESS. The incidence of the treatment adverse reaction in all the patients have significantly reduce(P<0.01).Conclusion1.The depression with anxiety symptom means the worse pathogenetic condition,higher risk of suicide, poorer response to antidepressants,as well as poorer prognosis contrast with patients who without anxiety.2. Venlafaxine and Escitalopram are both effective on the treatment of the depression associate anxiety symoptoms.3.Venlafaxine have better prognosist than Escitalopram in the treatment of the depreesion with anxiety symptoms.