The Clinical Study Of The Risk Of Permanent Hair Dye Use To Connective Tissue Disease With Positive Antinuclear Antibody

ObjectiveWe sought to investigate the risk of permanent hair dye use to connective tissue disease(CTD) with positive antinuclear antibody(ANA).MethodWe conducted a population-based case-control study to analyse440CTD patients from the Rheumatology department in Qilu hospital of Shandong University,and440paients’relatives or friends who were free from any CTD.Patients and controls were matched in sex and age.A face-to-face interview was adopted to finish questionnaires about subjects’demographic variables and hair dye use information,concerning years、frequency、range and allergy related to hair dye.Patients’case history was also record,such as disease diagnosis、disease course、primary symptom、serum tests and organs involvement. Statistical analysis was performed by means of the SPSS17.0software using χ2test and Logistic regression. All tests were two-sided, with a significance level of0.05.ResultsThe association between the use of permanent hair dye and CTD did not reach statistical significance (OR=1.282,95%CI:0.966-1.700, P=0.085),when it referred to SLE alone(included in CTD),we got the same result (OR=1.092,95%CI:0.795-1.500, P=0.587). When we chose dying times as the permanent hair dye exposure,there was no significant association between the exposure dose and the development of CTD. The case-only study showed that patients using permanent hair dye wasn’t a risk factor to organs involvement (the OR of CTD was1.019,95%CI:0.682-1.522; the OR of SLE was1.280,95%CI:0.785-2.086)Conclusion1. The case-control study showed that permanent hair dye use was not related to the development of CTD. With the hair dye exposure getting higher, the risk of CTD development did not increase.2. When it referred to SLE alone, we didn’t find association between permanent hair dye use and the development of SLE.3. The case-only study showed that patients using hair dye couldn’t increase the risk of organs involvement.