Analysis Of The Change Of Bacteria And Risk Factors Of Biliary Infection

【Objective】(1) To study the changes of biliary bacteria and their resistance toantibiotics in bile samples of patients with biliary tract infection.(2) To analyze the risk factors of biliary infection.【Methods】(1) The data of278strains of microbes were found in188patients withpositive bile culture from Oct2005to Oct2010and their resistance toantibiotics were analyzed retrospectively.(2) The data of278strains of microbes were found in188patients withpositive bile culture from Oct2005to Oct2010and the risks factors ofbiliary infection【Results】(1) There were65and102positive samples respectively in126samplesduring the first half of this study(2005—2008) and152ones during thesecond half(2005—2010)as well as70and118strainscultured．Gram-negative bacteria accounted for71.4%and65.8%andGram—positive accounted for28.6%and29.6.%.Esc herichia coli was themajor one and accounted for37.1%and31.4%.The rates of positive ESBLsbacteria was increasing(15.4%vs45.9%,p=0.011).The factor that influncedthe changes of pathogens was ERCP.(p=0.002)(2) The positive rate of bile bacteria culture was significamly higher inpatients who had been performed by biliary surgery (OR=2.28495%CI1.146-4.550,P=0.019). Patients with common bile duct stones had asignificantly higher positive culture rate than those without common bile duct stones(OR=2.73695CI1.607-4.658P=0.000)．【Conclusions】(1) The main pathogens of biliary infection are E.coli andEnterococcus．The rates of positive ESBLs bacteria was increasing.Thefactor that influnced the changes of pathogens was ERCP. It is importantto use antibiotics properly to control the infection of biliary tract.(2) History of biliary surgery and existence of common bile duct stoneshad an important influencc in the positive rate of bile bactaria culture．...