Analysis On Efficacy And Cost-effectiveness Of Four Treatment Methods Of Antibiotics For The Children With Acute Bronchial Pneumonia

Objective To observe the clinic effect of four antimicrobial treatment therapeutic schemes of acute bronchopneumonia in children, and make a cost-effectiveness analysis of four regimens for treatment of acute bronchopneumonia infection, then choose the regimen with better effectiveness and economical efficiency and hope to direct the clinical rational use of drugs.Methods According to meet the diagnostic criteria for children with acute bronchial pneumonia and give comprehensive treatment,194patients with acute bronchial pneumonia from Third Xiangya Hospital of Central South University during January2009to December2010, were collected and divided into four groups. Group A is cefoperazone sulbactam (1:1) group. Group B is amoxicillin/sulbactam group. Group C is amoxicillin clavulanate potassium group. Group D is cefminox group. At the same time, four groups were given antiviral Chuan Hu Ning freeze-dried powder for injection combination therapy and were observed in7days. Investigated the therapeutic effect of the programs from clinical efficacy, laboratory indicators and pathogenic bacteria clearance and made a cost-effectiveness analysis of four regimens.Results The four treatment regimens have good therapeutic effect and pathogenic bacteria clearance rate. The clinical curative rates were90.91%,91.13%,86.67%,94.74%, for group A, group B, group C and group D, the comparison between groups was not significant (P>0.05).(2) The ratio of cost-effectiveness was1444.48,1262.46,1185.60,1543.23, when we evaluated with the method of cost-effectiveness analysis, while the amoxicillin clavulanate potassium group has the lowest cost-effectiveness ratio.Conclusion United antiviral drugs for children with acute bronchial pneumonia, cefoperazone sulbactam (1:1), amoxicillin/sulbactam, amoxicillin clavulanate potassium and cefminox have equivalent antimicrobial effects, but amoxicillin clavulanate potassium is more economic than the other three programs.