Studies On Relevance Of The Relationship Between Internal Carotid Intima-media Thickness And Amnestic Mild Cognitive Impairment

Objective:The aim of this investigation is through measuring internal carotid artery intima-media thickness levels in patients with Amnestic mild cognitive impairment, to probe into the correlation between internal carotid artery intima-media thickness levels and Amnestic mild cognitive impairment, and to study the clinical significance.Methods:119inpatient, outpatient of neurology and healthy subjects from physical examination center aged45to80years were collected from the first people’s hospital of Chang De city, from2011.1to2011.11.The study set up case group (aMCI group) and control group (normal group), the aMCI group consisted of61middle-aged and elderly people.The normal group consisted of58healthy middle-aged and elderly people.Both groups whose clinical data and imaging data were collected performed neuropsychological assessment and carotid color ultrasound.Then we compared the level of internal carotid artery IMT and clinical data among two groups.Results:1.The incidence of hypertension、diabetes、smoking and dyslipidemia, also in the concentration of HbAlc and Hcy are dramaticlly higher among the case group than among the control group.There was no significant difference in body mass index、the incidence of hyperuricemia and drinking between the case group and the control group.2.The scores of MMSE and MoCA were dramaticlly lower in case group than in control group,p<0.001.3.The IMT of the left and right internal carotid among the case group were0.68±0.15(mm),0.69±0.14(mm).The IMT of the left and right internal carotid among the control group are0.58±0.15(mm),0.58±0.15(mm).The IMT are thicker among the case group than among the control group.There was statistical significance,p<0.05.4. There was no statistical significance between the levels of IMT in the left internal carotid and the IMT level in the right among the patients of case group.(t=0.44, P=0.66).5.The age is more older,the internal carotid artery IMT is more thicker.There was positive correlation between age and the level of internal carotid artery IMT,suggesting that age is a risk factor of internal carotid artery IMT6.There was negative correlation between the total scores of MMSE、MoCA and the level of internal carotid artery IMT,suggesting that the internal carotid artery IMT is more thicker,the degree of cognitive impairment is more serious. 7.There was no significant difference in the level of internal carotid artery IMT between female and male(P>0.05). Conclusion:This showed that amnestic mild cognitive impainnent had dramatic correlation with the level of internal carotid artery IMT,supporting that the occurrence of amnestic mild cognitive impairment had correlation with vascular factors.