Clinical Observation Of The Termination Early Pregnant With Mifepristone Associate With Misoprostol

Objective: To investigate the clinical effect of using Mifepristone in combination with Misoprostol to terminate early pregnancy between35to91days. The aim is to provide reference for increasing success ratio and reducing volume of vaginal bleeding of early abortion with drugs.Methods: To describe and analyze the information of women who desire early abortion with drugs voluntarily from January2000to December2009. That information includes general conditions, effects and potential influencing factors of subject with early abortion with drugs. Statistical software SPSS18.0which contain test to analyze single variable, non-logistic regression to analyze multiple variables were used for the data processing.Results:1. There were1197women who used Mifepristone in combination with Misoprostol to terminate early pregnancy. The successful ratio was91.65%. The results of the test of single factor were: there was significant difference in groups of age between17~34years and the age between35~40years (P<0.05). Successful ratio of the former was higher than the latter. There was no significant difference in groups of pregnancy between35～49days and50~91days (P>0.05) This means that successful ratio was no difference between the two groups. There was significant difference in groups who have pregnancy history and not (P<0.05). There were significant difference in groups who have delivery history and not (P<0.05). Comparing the rate of complete abortion in anteversion and retroversion position of uterus, there was significant difference between them (P<0.05).The successful ratio of anteversion was higher than that of retroversion. The results of non-logistic analysis of the effect of the successful ratio of using Mifepristone in combination with Misoprostol to terminate pregnancy were: the delivery experience (OR=2.19,95%Confidence interval is1.44~3.34) and the retroversion position of uterus (OR=1.83,95%Confidence interval is1.20～2.79) were risk factors of the successful ratio of terminating early pregnancy.2. The ratio of large volume of vaginal bleeding of women who used Mifepristone in combination with Misoprostol to terminate pregnancy was43.27%. The single variable analysis results showed that there was significant difference in the volume of vaginal bleeding in groups of age between17～34and that of35～40(PO.05). The latter’s volume of vaginal bleeding was more than the former. There was significant difference in volume of vaginal bleeding in groups of gestational age between35～49days and that of50～91days (P<0.05). The latter’s volume of vaginal bleeding was more than the former. There was significant difference in volume of vaginal bleeding in groups who have pregnancy history and not (P<0.05). There were also significant difference in volume of vaginal bleeding in groups who have delivery history and not (P<0.05). The volume of vaginal bleeding of women who had pregnancy history were more than those not, so do the women who had delivery experience. Comparing the volume of vaginal bleeding in anteversion and retroversion position of uterus, there were no significant difference between them(P>0.05). This means that there is no difference in volume of vaginal bleeding between the two groups. The results of non-logistic analysis of the volume of vaginal bleeding of using Mifepristone in combination with Misoprostol to terminate pregnancy were gestational age between50~91days (OR=1.64,95%CI is1.20~2.23), pregnancy experience (OR=1.97,95%CI is1.43～2.70) and delivery experience (OR=1.48,95%CI is1.12～1.95) were the risk factors of large volume of vaginal bleeding.Conclusion: The successful ratio of using Mifepristone in combination with Misoprostol to terminate early pregnancy is related to age, pregnancy history, delivery history, and the position of uterus. Having delivery history and retroversion position of uterus are risk factors of unsuccessful terminating of early pregnancy. The volume of vaginal bleeding of using Mifepristone in combination with Misoprostol to terminate early pregnancy is related to age, gestational age, pregnancy history and delivery history. Gestational age between50～91days, pregnancy experience and having delivery history are risk factors of more volume of vaginal bleeding.