Study On The Relationship Between Distribution Of Gamma-glutamyl Transferase And Multiple Metabolic Disorders And Its Clustering Situation In Korean-Chinese And Han Men Of Yanbian Rural Areas

Objective To analyze the relationship between distribution of gamma-glutamyl transferase (GGT) and multiple metabolic disorders and its clustering situation in Korean-Chinese and Han men of Yanbian rural areasMethods1) Using a simple random sampling method,1,708residents aged30-70years, who living in selected rural areas of Yanbian were examined from July2008to July2009. All subjects knew the informed consent.2) The data for this study were collected by the family visit, including the general information, past history and family history of cardio cerebral vascular diseases, etc.3) Height, weight, waist circumference, hip circumference and blood pressure was measured by physical examination.4) GGT, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), blood glucose and other indexes were measured after12hour fasting.5) GGT was returned by the base-10logarithm and tested. Normal distribution measurement data were tested by the t-test, the numeration data were tested by the χ2-test. The influencing factors of GGT disorder were analyzed by multivariate logistic regression analysis, GGT disorder as the dependent variable and age, race, smoking, drinking, education, overall obesity, central obesity, low-HDL-C, high-TG, high-TC, hypertension, hyperglycemia and MS as independent variable; the variables were selected by BACKWARD, selected variables were significant level as α=0.05and deleted variables were significant level as α=0.1.Results Of1,708subjects,910were Korean-Chinese and798were Han Chinese. Korean Chinese comprise40.9%and were slightly older than Han Chinese (53.26±9.83vs.49.70±10.17years).1) The level of GGT among Korean men (1.52±0.37) was significantly higher than among Han men (1.40±0.29,t=7.264; P<0.01), and the prevalence of GGT disorder in Korean men (22.6%,260/1018) was significantly higher than in Han men[(9.6%,130/983),χ2=51.408, P<0.000].2) The level of BMI, WC, SBP, DBP, TG and FBG, and the prevalence of overall obesity, central obesity, hypertension, high-TC, high-TG, hyperglycemia (Han Chinese) and MS was progressively higher with the increases of the level of GGT among Korean and Han men (all P<0.01).3) The prevalence of central obesity (38.1%/28.7%), hypertension (70.4%/59.3%), hyperglycemia (12.6%/11.2%), high-TG (37.6%/26.4%) and MS (31.1%/21.1%) in Korean men was significantly higher than in Han men (P<0.01).4) It was accompanied IR that8.0%of patients with non-abnormal metabolism,14.3%of patients with one kind of abnormal metabolism,21.3%with two kinds of abnormal metabolism with IR,27.7%with three kinds of abnormal metabolism,40.5%with more than four kinds of abnormal metabolism in Korean-Chinese, and that in Han was2.2%,7.0%,9.3%,16.5%,20.0%, respectively. The levels of GGT and the prevalence of GGT disorder were increased along with the increment of metabolic disorder numbers in both nationalities.5) Our single variable analysis showed that the prevalence of GGT disorder was increased along with the age (Korean), smoking (Korean) and drinking, and that in group with hypertension, high-TG, high-TC (Korean), central obesity (Korean), hyperglycemia (Han Chinese) was significantly higher than in normal group (P<0.05).6) Our multivariate logistic analysis showed that GGT disorder was closely related with race, age, smoking, drinking, overall obesity, low-HDL-C, hypertension, central obesity, high-TC, high-TG and MS, and dose-response relationship was seen between GGT disorder and age, smoking and drinking.Conclusion1) The level of GGT and the prevalence of GGT disorder in Korean men was significantly higher than in Han men of Yanbian rural areas.2) The level of BMI, WC, SBP, DBP, TG and FBG, and the prevalence of overall obesity, central obesity, hypertension, high-TC, high-TG, hyperglycemia and MS was progressively higher with the increases of the level of GGT.3) The levels of GGT and the prevalence of GGT disorder were increased along with the increment of metabolic disorder numbers in both nationalities.4) The prevalence of GGT disorder was positively correlated with race, age, smoking, drinking, overall obesity, low-HDL-C, hypertension, central obesity, high-TC, high-TG and MS, and dose-response relationship was seen between GGT disorder and age, smoking and drinking.