Relationships Between Visceral Adipose Thickness And Cardiometabolic Risk Factors

objective: In recent years, morbity of obesity and cardiometabolicdisease are gradually increasing. Visceral fat (VF)accumulation is suggested tobe a major contributor to such cardiometabolic risk factors as hypertension,insulin resistance, and hyperlipidemia. We have devised the ultrasonographic(USG) measurements of visceral fat thickness(VFT)to estimate VFaccumulation, and investigated the relationship between VF and cardiometabolicrisk factors.To provide the evidence of treating obesity related cardiometabolicdisease by means of ruducing VF accumulation. Methods: Five hundredeighty-three patients were included. All patients were observed to surveysystolic(SBP) and diastolic blood pressure(DBP), ambulatory bloodpressure(AMBP), the height, body weight, hip circumference and waistcircumference(WC), then calculated the body mass index(BMI)and thewaist-to-hip ratio(WHR). Four hundred ninety-one patients were collectedvenous blood to assay fasting plasma glucose(FPG), fasting insulin(FIN), totalcholesterol (TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-c),low density lipoprotein cholesterol(LDL-c), apolipopoprotein a(Apo-a),apolipopoprotein b(Apo-b), and serum uric acid (UA), to run oral glucosetolerance test and insulin releasing test. Insulin resistance was estimatedusing HOMA-IR formula. All Patients were divided into two groups: the groupwith excessive VF accumulation, the group with normal VF accumulation. Contrast BMI, WC, WHR, SBP, DBP, AMBP,glucose, insulin,HOMA-IR,UA and lipid parameters between the two groups. All Patients weredivided into five groups based on quintiles of VFT, Contrast AMBP andmorbidity of hypertension among these five groups. Results: Compare to thegroup of normal VF accumulation, insulin level, TG, Apo-b, HOMA-IR, UA,DBP, AMBP, BMI and WC are significantly higher(p<0.05)in the group ofexcessive VF accumulation. There was no relation between SBP, as well asglucose, and VFT in both groups (p>0.05). Mean blood pressure of entire day,mean blood pressure of daytime, mean blood pressure of nighttime, bloodpressure bload of entire day, blood pressure bload of daytime,blood pressurebload of nighttime and morbidity of hypertension is significantly lower whenVFT (24-33mm)(p <0.05). Conclusion:1. VFT is closely correlated to BMIand WC, they are reflect the degree of obesity to some extent.2. VFT is closelycorrelated to lipid, UA, insulin resistance, resulting in metabolic dysfunction.3.VFT is closely correlated to mean blood pressure,blood pressure bload andmorbidity of hypertension. As VFT increaseing, the change trend of mean bloodpressure,blood pressure bload and morbidity of hypertension is U-shaped curve.4. There are the gender differences in the influence of VFT on the detectin rateof hypertension, female is a protective factor.5.VFT may be an importantindependent predictor of cardiometabolic risk factors.