Research On Fluticasone Propionate Cream

Dermatitis and eczema is a common multiple skin disease.It is generally divided into internal and external factors. Internal factors are genetic, mental health, endocrine and so on. Directing contact with chemical reagents, seafood, jewelry and others are external causes. Internal and external causes are closely linked interaction. Glucocorticoid treatment of dermatitis and eczema are more at this stage, although most effect of the glucocorticoid are perfect, it happens easy-dependent and even glucocorticoid-dependent dermatitis.Now a new type of glucocorticoid preparation which is made into a topical cream preparations is very convenient,effective when used and increasing the safety of the drug.The topics to fluticasone propionate as a model drug for the paraffin wax ointment bases, cetyl alcohol polyether-20emulsifier, to the antioxidant imidazolidinyl urea was prepared containing0.25%fluticasone propionate cream preparation, and its conducted the following studies:First of all, according to the indications characteristics preparation prepared to be cream at the part of preformulation studies.As the main principles of suitable viscosity, uniformity consistency and good stability, select liquid paraffin as a cream base and the corresponding emulsifiers, preservatives and other excipients for the physical and chemical properties of fluticasone propionate.Preparation of fluticasone propionate cream in the physical appearance, pH, viscosity and stimulating the study, the results are in line with the requirements of ointment preparations.At the quality standard part of the study, according to the characteristics of drugs and the the creams requirements of pharmacopoeia, control the quality of various indicators.To ensure drugs’ safety inspecting of a variety of methods, such as the preservative content,it is easy to provide a theoretical basis for stability of the experiment.The subject of fluticasone propionate cream initial stability, the use of accelerated testing and evaluation of long-term stability test the stability of pharmaceutical preparations and pharmaceutical preparations of the forecast period:shading,closed, below30℃can be stored under the conditions of2years.Finally,we have a transdermal absorption,contrast experiment in vitro with fluticasone propionate cream and the inspection of the methodology.