Influence Of Beating Heart Surgery On Renal Function

Objective: To investigate the effects on the blood urea nitrogen、 serumcreatinine andα1microglobulin by cardiopulmonary bypass with beatingheart or arrested heart.Methods:Fourty rheumatic heart disease (RHD) patients underwentmitral valve replacement were randomly assigned into two groups. For groupB,Twenty patients were under mild hypothermia by cardiopulmonary bypasswithout cross-clamping the aorta, and the remaining twenty patients (group C)had conventional surgery with hypothermic bypass and cardioplegic arrest aftercross-clamping the aorta. Blood samples were taken before operation、at the endof the operation、or6h、12h、24h and48h after operation for determination of theblood urea nitrogen(BUN)serum creatinine(SCr)andα1microglobulin(α1-MG).Results:⑴Patient’s demographics and operational procedures werecomparable in both groups with no further differences in operation proceduresregarding palliation or correction.⑵BUN、SCr and α1-MG levels increasedsignificantly after operation compared with the baseline values in bothgroups(P<0.05)．There were no significant differences between the two groupsat the corresponding time points(p>0.05).BUN、SCr and α1-MG levels Wereremain increased significantly on the12hours and24hours afteroperation(p<o．05) as compared with the baseline values in both groups. In group B,BUN and α1-MG still had increased significantly on the48hours afteroperation(P<0.05)as compared with the baseline values．Conclusion: There were no significant differences between beating heart orarrested heart groups on the effect of BUN、SCr and α1-MG.