The Relation Between AASI,Carotid Artery Ultrasound And Coronary Heart Disease

Background and Purpose:The changes in the structure and function of arterial wall are closely related with the morbidity of cardiovascular disease. With age increasing, vascular stiffness increases and systolic blood pressure and pulse pressure increases, so that the composition of the vessel wall and shear stress change, further exacerbating the hardening of the arteries. As the elastic component decreased and the inelastic component increased, the thickness of arterial wall and vascular intima-media are thickening, the vasodilator and elasticity of arterial are decreasing, and the arterial stiffness are increasing. Those have been shown to cause adverse cardiovascular prognosis. In order to study the relation between the arterial elastic properties and coronary artery disease and its clinical significance, the ambulatory arterial stiffness index (AASI), intima-media thickness (IMT) and plaque formation index have been used increasingly in clinical studies as they are the simple and reproducible non-invasive techniques. In this paper,24h ambulatory blood pressure monitoring and carotid ultrasound technology are combined, and research the correlation and its clinical significance between AASI, carotid atherosclerosis, serum hr-CRP and coronary artery disease.Materials and Methods:Retrospectively analyzed the general information, coronary angiography, carotid ultrasound test results and24h ambulatory blood pressure monitoring data of468hospitalized patients in the Cardiology Department from2009November to2011October. The IMT, carotid artery plaque number, plaque score, plaque surface conditions and internal echo are assessed based on carotid ultrasound test results. Analysis the24h blood pressure monitoring results of all selected objects and calculate the AASI. At the same time, we calculate the Gensini’ score for all selected objects through coronary angiography. All subjects were divided into coronary heart disease group (CHD) and non-coronary heart disease group (control group) by coronary angiography; The patients in the CHD group were divided into three groups:single vascular disease group, double vascular disease group, triple vascular disease group; According to coronary angiography, the patients in the CHD group were divided into two groups:narrow group and occlusion group. All selected subjects were divided into ACS group, AS group and control group. To analyze the AASI, IMT, plaque score, plaque incidence and Gensini’scores of each group, and to determine its clinical significance.Results:(1)The gender composition, age, BMI, SBP and DBP, PP, left ventricle diastole diameter, ejection fraction, hypertension, diabetes and coronary heart disease and family history between CHD group and normal control group were no significant differences.In CHD group, smoking, Hyperlipidemia, hr-CRP, AASI, IMT, carotid plaque score and carotid artery plaque incidence was significantly higher than these in normal control group.(2) SBP, DBP and PP between the three groups were no significant differences. CIMT and hr-CRP ware no related with coronary artery lesions; AASI and plaque score coronary score was positively correlated with coronary artery lesions.(3) The difference of SBP, DBP and PP between the three groups was no statistically significant; AASI, atherosclerotic plaque score and coronary score was positively correlated with coronary artery stenosis.(4) AASI,hr-CRP and carotid artery atherosclerotic plaque incidence comparison:ACS group>SA group>control group.Conclusion:(1) AASI, plaque score in patients are more important to prompted the range and severerity of coronary lesions than IMT and carotid artery plaque incidence.(2) AASI, hr-CRP and carotid artery atherosclerotic plaque was more correlated with CHD stability than IMT.(3) Gensini score is not directly related to the stability of CHD condition.