Prognosis Correlation Analysis Post-allogeneic Hematopoietic Stem Cell Transplantation In Hematological Malignancies

Objective：To study the risk factor affecting prognosis post-allogeneic hematopoieticstem cell transplantation(allo-HSCT)in hematological malignancies.Methods：We retrospective analyzed data from134consecutive patients undergoingallo-HSCT for hematological manignancies from January2003to April2011,to studythe correlation between sex、age、HLA consistency degree、donor source、revehentCD34+count、disease risk stratification、LC30、PLT30、WBC30、diagnosis transplanttime interval and5years overall survival(OS)、5years relapse rate(RR)、5yearsnonrelapse mortality(NRM).Results：In univariate analysis the lymphocyte count on day30(LC30) above0.4×10~9/L was associated with superior overall survival ｛（63.5±5.5）%vs.(37.0±8.6)%，P=0.001｝，less relapse｛（16.2±4.6）%vs.(34.4±10.7)%，P=0.035｝， less nonrelapse mortality｛（28.5±5.4）%vs.(45.0±9.3)%，P=0.020｝.Platelet counton day30(PLT30) above29×109/L was associated with superior overall survival｛（62.8±5.6）%vs.(37.7±8.6）%，P=0.004｝，less relapse ｛（16.0±4.9）%vs.(34.7±9.5)%，P=0.008｝。Low risk disease was associated with superior overallsurvival｛（65.3±6.6）%vs.(47.8±6.6)%，P=0.047｝，less relapse｛（6.1±3.4）%vs.(33.8±7.2)%，P=0.002｝。Other factors such as sex、age、HLA consistency degree、donor source、revehent CD34+count、WBC30and diagnosis transplant time intervalhave no correlations with prognosis. Multivariate analysis also suggested that LC30was associated with OS and NRM，platelet count on day30was associated with OSand RR，disease risk stratification was associated with OS and RR.Conclusion：LC30、PLT30and disease risk stratification are highly associated withprognosis, which could be the independent prognosis index after allo-HSCT inhematopathy and can identify a group of patients who might be suitable candidatesfor early interventions treatment.