Expression And Clinical Significance Of EZH2and P53in Colorectal Carcinoma

Aims: To investigate the expression and clinicopathologic significance of enhancerof zeste homolog2(EZH2) and P53in normal colorectal mucosa specimens,colorectaladenoma and colorectal carcinoma, and study the role of EZH2and P53in the tumor andtheir possible implications.Methods:20cases of normal colorectal mucosa,20cases of colorectal adenomaand40cases of colorectal carcinoma were examined by Immumohistochemical staining.Results: The positive rates of EZH2in normal colorectal mucosa specimens,colorectal adenoma and colorectal carcinoma were5%、70%and75%, respectively. Thedifference among colorectal adenoma, colorectal carcinoma and normal colorectal mucosaspecimens was significant (P<0.01). But the difference between colorectal carcinoma andcolorectal adenoma was no significant (P>0.05). The high expression of EZH2in colorectalcarcinoma was found to be associated to the Dukes stages and lymphatic metastasis, butunrelated to sex, age and degree of differentiation of carcinoma(p>0.05). The positive rateof P53in cancer group (62.5%) was observably higher than in adenoma group (20%) and innormal colorectal mucosa group (0%)(p<0.01). But there was significant differencebetween and (p<0.05). With the increased Dukes stages and lymphatic metastasis (p<0.05),the positive rate of P53in colorectal carcinoma was enhanced and was not associated to sex,age and degree of differentiation of carcinoma. The expression of EZH2and P53proteinswere significantly positively correlated (r=0.881, p<0.05). Conclusions: Upregulation of EZH2and P53proteins expression exist in colorectalcarcinoma and may play pivotal roles in the progression of colorectal carcinoma. EZH2andP53promote cell proliferation through interaction, and participate in progression, invasionand metastasis of colorectal carcinoma.