Prevalence And Risk Factors Of Hypertension In Chinese With Increased Risk For Diabetes

Objective: To determine the prevalence and risk factors of hypertension inChinese subjects with increased risk for diabetes.Research design and methods: A total of1147Chinese people with increasedrisk for diabetes were randomly included. All the subjects were surveyed byquestionnaires, and physical examination, OGTT test, HbA1cand insulindetermination were carried out. HOMA-IR and HOMA derived Beta-cell function(HOMA-β) were also calculated. The Selected populations were divided into threegroups, based on the levels of blood glucose. i.e. the normal blood glucose group,the pre-diabetes group and the newly diagnosed diabetes group. Logistic regressionanalyses were conducted to evaluate the independent risk factors associated withhypertension.Results: A total of958eligible patients with complete information werescreened from1147Chinese people with increased risk for diabetes between May2009and August2011. Of them,55.6%were men,44.4%were women, aged49.0(41.0-57.0) years old, Among them,39.5%met the screening definition forhypertension,61.7%diagnosed as diabetes，60%for overweight and obesity，57.2%for insulin resistance，41.4%for dislipidemia. The prevalence of hypertensionincreased with the levels of blood glucose:22.1%for the normal blood glucose group, 34.9%for the pre-diabetes group and44.7%for the newly diagnosed diabetes group.Age(middle-aged and elderly), BMI(overweight and obesity), dislipidemia,2h-plasmainsulin were independently associated with hypertension of eligible patients; Amongthe subgroups, BMI(overweight and obesity) was independently associated withhypertension in normal blood glucose group; age(elderly),BMI(overweight andobesity), dislipidemia,2h-plasma insulin, Fasting plasma glucose were independentrisk factors of hypertension in pre-diabetes group; age(middle-aged and elderly),BMI(overweight and obesity), dislipidemia, HOMA-β were independent risk factorsin patients with diabetic hypertension.Conclusions: This is the first report of comparing hypertensive risk factors amongdifferent states of blood glucose in Chinese subjects with increased risk for diabetes.Fasting plasma glucose，BMI，age，dislipidemia，2h-plasma insulin and HOMA-β arekey points of cutting down the prevalence of hypertension in diabetic high risk group.The roles they play for the increase in blood pressure vary from different subgroups.BMI(overweight and obesity) is always independently associated with hypertensionin three subgroups; age(elderly) and dislipidemia are independent risk factors forpre-diabetic and diabetic hypertension;2h-plasma insulin and Fasting plasma glucoseare independent risk factors only for pre-diabetic hypertension; age(middle-aged) andHOMA-β are only independently associated with diabetic hypertension.