Study Of The Association Between Dietary Patterns,Adipokines And Obesity

Objective:1. This study aimed to understand dietary intake, nutritional status and the prevalence of obesity in newlyweds, and characterize the dietary patterns of newlyweds married within one year and to examine the factors associated with weight changes.2. To examine whether serum Ccdc80, Ghrelin, GIP, Leptin or Resistin levels were related to obesity, FBG and insulin resistance, and provide theoretical basis for exploring their physiological functions.Methods:1. A cross-sectional study was carried out in2009with a sample of342pairs of newlyweds in Shanghai Baoshan district, China. Weight and height were measured and food intake was measured based on49-item food frequency and3-day24hours recall questionnaires. Dietary patterns were identified through factor analysis, and the factors associated with weight changes were determined by multiple linear regressions.2. We collected serological samples from non-diabetic and diabetic population from Tangshan Chinese Medicine Hospital, detected their serum Ccdc80levels by using sandwich ELISA methods, and serum Ghrelin, GIP, Leptin and Resistin by Bio-plex Suspension Array System.Results:1. Of the342pairs, a total556participants (281males and275females) were included in the analyses. Average weight gain of the participants during marital transition was1.9kg (2.2kg for men and1.6kg for women). Four major dietary patterns were identified:vegetable pattern, sweets and fats pattern, legume pattern and poultry, beef and mutton pattern. In multivariate analyses, the highest quintile of factor2(sweets and fats pattern) was significantly associated with weight gain after marriage in a comparison with the lowest quintile (P=2.94;95%CI:0.75,5.15; p=0.01) in men. The highest quintile of factor4(poultry, beef and mutton pattern) was inversely associated with weight gain after marriage in a comparison with the lowest quintile (β=-1.21;95%CI:-2.32,-0.11; p=0.03).2. In non-diabetic population, we found no significant differences between serum Ccdc80, Ghrelin, Resistin and different body weight groups (p>0.05) using Pearson Partial correlation analysis, besides, we found a positive association between Leptin and BMI(r=0.80, p<0.001), WC (r=0.80, p<0.001), WHR (r=0.56, p<0.01); GIP was also positively associated with与BMI(r=0.34, p<0.05) and WC(r=0.33, p<0.05). In the diabetic and non-diabetic population, we found that FBG, HOMA-IR, TG showed a negative correlation with Ccdc80, while HDL-C showed a positive correlation with serum Ccdc80; besides, FBG, HOMA-IR, TG showed a positive correlation with Ccdc80, while HDL-C showed a negative correlation with serum Ccdc80Conclusions:1. Our results suggest that a pattern rich in sugar, oil and condiments may lead to greater marital weight gain in men, another pattern rich in poultry, beef and mutton may lead to less marital weight gain in both men and women.2. In this part of study, we found that serum Ccdc80had a negative correlation between FBG and HOMA-IR, while Leptin had a positive correlation between BMI, FBG and HOMA-IR, suggesting that Ccdc80may be playing a protective role in diabetes, while serum Leptin was a risk factor of obesity and diabetes.