The Impact On Coagulation Of Radiofrequency Catheter Ablation For Supraventricular Tachycardia

[Objective] To observe the changes of the blood coaguable states due to radiofrequencycatheter ablation (RFCA) and The predictive significance of thrombotic disease.[Methods]Selected68patients who underwent RFCA in treatment subject. The plasma levels of D-dimer, platelet-granule membrane glucoprotein (GMP-140), The thromb in-antithrombin Ⅲ complex (TAT) were assayed by Enzyme-linked Immuno Sorbent Assay (ELISA).Blood samples were obtained by inserting veins before RFCA was performed, just at thetime that RFCA was accomplished, the third day and the seventh day after RFCA.[Results]The plasma levels of D-dimer increased distinctly just the time RFCA wasperformed(2.28±0.09mg/l）,and restored in the seventh day after RFCA, contrasted to thelevels of those before RFCA was performed. While the peak level of GMP-140waspresented in the third day after RFCA, which was3.0times the initial one. Plasma TATexhibited a double peaked pattern: the first peak occurred instantly after RFCA (42.9±15.8ng/m l), and the second peak at3days later(20.3±19.2ng/m l). TAT is still higherthan the former level of RFCA at the seventh day after RFCA,[Conclusion] RFCA maychange the blood coaguable states by increasing the levels of the bloodcoaguablesubstances. Throm bogenesis caused by RFCA has2phases: the acute phase atinstantly after the procedure and the delayed phase at3days later. Monitoring the plasmalevels of D-dimer,GMP-140,TAT is valuable in guiding theadministration ofanticoagulative drugs and prophylaxis of thromboembolic events.