Association Study Of Dopamine D2Receptor Gene Polymorphisms And The Risk Of Drug Induced Movement Disorders—Levodopa-induced Dyskinesia In PD, Artane-induced Oral Dyskinesia In Pd And Antipsychiatric Drug-induced Tardive Dyskinesia

Backgrounds:With the time goingon, People have found that the drug not only can be used to prevent and treat the one’s disease, but also can induced side effects. Drug induced movement disorders were often reported by doctors everywhere. There are classification of Drug induced movement disorders:1. Acute movement disorders, include Acute dystonic reactions, Parkinson’s Syndromes and some else.2.Tardive Syndromes, include Tardive Dyskinesia, Tardive dystonic reactions, tremor, myoclonus and so on. Now the pathological mechanisms are not clear.It has been demonstrated that genetic factors may play an important role in the occurrence of Tardive movement disorders by Drug Many studies of all over the world proved the association between Dopamine D2receptor gene polymorphisms and the risk of Tardive Syndromes However, the results are not the same for the selection at the different DRD2gene site. Our study is to investigate the possible association between Dopamine D2receptor gene polymorphisms at Taq I site and the risk of Drug induced movement disorders-Levodopa-induced dyskinesia in PD, Artane-induced oral dyskinesia in PD and Antipsychiatric drug-induced tardive dyskinesia.Objective:To investigate the possible association between Dopamine D2receptor gene polymorphisms and the risk of Drug induced movement disorders-Levodopa-induced dyskinesia in PD, Artane-induced oral dyskinesia in PD and Antipsychiatric drug-induced tardive dyskinesia.Methods:To observe the clinical display of LID, Artane-induced oral dyskinesia and TD. PCR-RFLP was used to perform genotyping on Dopamine D2receptor gene polymorphisms at Taq I site from Levodopa-induced dyskinesia in PD, Artane-induced oral dyskinesia in PD and Antipsychiatric drug-induced tardive dyskinesia.Chi-square and ANOVA were employed for statistical analysis.Results:1. There are no statistically significant differences in the distribution of DRD2TaqⅠ A and B alleles between LID and non-LID cases,but there are statistically significant differences in the distribution of TaqⅠA and B genotypes.2. There are no statistically significant differences in the distribution of DRD2TaqⅠ A and B alleles between Artane-induced oral dyskinesia in PD and non-oral dyskinesia cases,but there are statistically significant differences in the distribution of TaqⅠ A and B genotypes.3. There are no statistically significant differences in the distribution of DRD2TaqⅠ A and B alleles and genotypes between TD and non-TD cases.Conclusion:1.There may be association between DRD2gene TaqⅠ A and B polymorphisms and genetic susceptibility of LID in PD.2. There may be association between DRD2gene TaqⅠ A and B polymorphisms and genetic susceptibility of Artane-induced oral dyskinesia in PD.3. There may be no association between DRD2gene TaqⅠ A and B polymorphisms and genetic susceptibility of Antipsychiatric drug-induced tardive dyskinesia.