Effects Of Shengmai Injection Combined With Non-nutritive Sucking On Preterm Infants With Feeding Intolerance

Background:In preterm infants especially in premature infants of very low birth weight, the incidence rate of digestive dysplasia and feeding intolerance were higher.The feeding intolerance in preterm infants can lead to zero gain weight or even negative gain weight, backward in physical and intellectual development, and the extending of intravenous nutrition time.The risk of necrotizing enterocolitis, infections and suffocation by inhalation is also increased. Past studies has reported that the domperidone, metoclopramide or cisapride can be used for the therapy of feeding intolerance in preterm infants, but some side effects on central nervous system, heart and liver were found in clinical therapy. Therefore the drug use was restricted in clinical application. Shengmai injection as a safe and effective traditional Chinese medicine has been proven to improve circulation guarantee in intestinal blood perfusion, nonspecific anti-inflammatory and immune function. Non-nutritive sucking can promote the maturation of gastrointestinal motility by stimulating the vagus nerve and promoting releasing of gastrointestinal hormones. Therefore, the combination of Shengmai injection with non-nutritive sucking should be improving the therapy effects on promoting the maturation of gastrointestine, relieving feeding intolerance symptoms and promoting the growth of pretum infants.Objective:To observe the infant nutrition, promoting growth effect and safety under the feeding by nasogastric tube, nutrition support on the basis of conventional therapy combined with Shengmai injection and non-nutritive sucking on preterm infants with feeding intolerance.Methods:Selected156cases of preterm infants with feeding intolerance as the research projects. All of the preterm infants were no congenital malformation and metabolic disease. All of the patients need feeding by nasogastric tube. The cases were randomly divided into4groups:40cases in control group with routine therapy by nasogastric tube feeding, parenteral nutrition support and Blu-ray irradiation treatment.34cases in Shengmai group: On the basis of routine therapy, Shengmai injection was given by intravenous infusion as5ml/d.32cases in non-nutritive sucking group:On the basis of routine therapy, non-nutritive sucking was given.50cases in combination group:On the basis of routine therapy, Shengmai injection and non-nutritive sucking was simultaneously given.The effects of feeding and the changes of liver function on the preterm infants with feeding intolerance were observed and comparied in the four groups.Results:The abdominal distention and gastric retention time, recovery time to birth weight, reaching full enteral feeding time, the jaundice extinction time and the length of stay were significantly shorten in Shengmai group, sucking group and combination group compared with the control group (p<0.05or p<0.01).The levels of serum total bilirubin and indirect bilirubin at different time (3,7,14d) are significantly reduced (p<0.01) in above three groups compared with control group.The changes in combination group was significant compared with the Shengmai group or sucking group(p<0.05). The various associated complications in the three groups were less than that in control group. It was significant difference between combination group and control group(P<0.01).The level of serum albumin on seventh day and fourteenth day was increased obviously in Shengmai group, sucking group and combination group compared with that in control group (p<0.05or p<0.01), suggesting that the therapy especially the combination therapy plays a promoting role on the preterm infant nutrition. The related liver function index was no changes during the treatment process.Conclusion:1. The therapy effects of Shengmai injection or non-nutritive sucking are better than traditional routine treatment on preterm infants with feeding intolerance, and the combination of Shengmai injection with non-nutritive sucking is more effective.2. Combined application of Shengmai injection with non-nutritive sucking is beneficial to the growth and development of premature infants.