| ObjectiveTo explore the expression and clinicopathologic significance of MnSOD andSBP1in colorectal carcinoma and adenoma.MethodsExpression of MnSOD and SBP1in normal colorectal tissues, colorectalcarcinoma and colorectal adenoma were evaluated by immunohistochemistryand RT-PCR. The relationship between expression of MnSOD and SBP1incolorectal adenoma and clinical parameters was analyzed.ResultsThere was negative expression of MnSOD in adjacent correspondingcolorectal tissues. The positive expression rate of MnSOD was44%（11/25）incolorectal adenoma and76%（19/25）in colorectal carcinonma. Contrasted tocolorectal adenoma and its adjacent tissues, MnSOD expression in coloretlcarcinoma was obviously increased （P＜0.05）.The expression of MnSOD waspositively correlated with histopathobigical grades （P＜0.05）,but not with otherclinicopathological factors（P＞0.05）.There was negative expression of SBP1in colorectal carcinoma. Thepositive expression rate of SBP1was72%(18/25) in colorectal adenoma and88%(22/25) in adjacent corresponding colorectal tissues. Compared withcolorectal adenoma and adjacent tissues, expression of SBP1in colorectalcarcinoma obviously decreased （P＜0.05）.The expression of SBP1waspositively correlated with histopathobigical grades （P＜0.05）,but not with otherclinicopathological factors（P＞0.05） ConclusionsThe expression of MnSOD may be associated with carcinogenesis andprogression of colorectal carcinoma，perhaps becoming a new biomarker. Thelow expression of SBP1may be associated with carcinogenesis an progression ofcolorectal carcinoma. Our findings may provide a basis for future studiesconcerning the molecular mechanisms of SBP1in tumorigenesis as well as apossible role of selenium in chemoprevention and treatment of colorectalcarcinoma. |
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