Associations Of Osteoporosis And Carotid Atherosclerosis In The Elderly Male People

Objective:To study the associations of osteoporosis and carotid atherosclerosis in theelderly male peopleMethods:One hundred and twenty five elderly male patients who admitted to our hospitalwere enrolled in this study. All patients underwent DXA examination to determine thebone mineral density (BMD) of the vertebra and the femoral head. They alsounderwent the ultrasonography of the carotid arteries of the both sides and theintima-media thickness (IMT) and the atherosclerotic plaques were measured.According to the BMD and the IMT values, the patients were divided intoosteoporosis group and non-osteoporosis group, normal intima-media thickness groupand thickening group. Record and measure their general conditions, existentcardiovascular diseases’ risk factors, relevant blood biochemical indices, IMT values,BMD values and relevant serum bone markers level. Then we did a set of statisticanalysis with SPSS17.0software.Results:1. Patients in the osteoporosis group had a significantly older age than the onesin the non-osteoporosis group(P＜0.05). Patients in the osteoporosis group had asignificantly lower BMI than the ones in the non-osteoporosis group (P＜0.05).Compared with the non-osteoporosis group, the osteoporosis group had a significantlyhigher incidence of increased IMT and atherosclerotic plaques (P＜0.05). Patients inthe osteoporosis group had a significantly higher serum TC, TG and LDL level (P＜0.05) but a lower serum HDL level (P＞0.05) than the ones in the non-osteoporosisgroup. There were no significant differences in the serum C_a, PO4and FBG levelbetween the two groups (P＞0.05).2. The osteoporosis group had a significantly lower BMD than the non-osteoporosis group (P＜0.05). Compared with thenon-osteoporosis group, the osteoporosis group had a significantly higher serum PTH,TP1NP and CTX level (P＜0.05), but a lower serum VD total and N-MID level(P＜0.05). The Spear correlation analysis showed that the serum TP1NP, PTH, CTX levelwas negatively correlated with the BMD, but the serum VD total and N-MID levelwas positively correlated with the BMD (P＜0.05).3. The proportion of smoking,hypertension, diabetic mellitus (DM), coronary heart disease and hyperlipidemia weresignificantly higher in the osteoporosis group than that in the non-osteoporosis group(P＜0.05).4. Multivariate unconditional logistic regression analysis showed thatcoronary heart disease and hyperlipidemia were the major risk factors of osteoporosisin the elderly male patients, and BMI was the protective factor of osteoporosis(P＜0.05).5. Compared with the normal intima-media thickness group, the thickeninggroup had a significantly lower BMI and BMD (P＜0.05). The thickening group alsohad a significantly higher serum PTH, TP1NP and CTX level (P＜0.05) and a lowerserum VD total and N-MID level(P＜0.05).6. Multivariate unconditional logisticregression analysis showed that hyperlipidemia and DM were the major risk factors ofcarotid atherosclerosis in the elderly male patients and osteoporosis was also a riskfactor of carotid atherosclerosis (P＜0.05).Conclusion:Osteoporosis is a systematic disease with the lower BMD and the change ofserum bone markers level. It is closely correlated with the cardiovascular diseases riskfactors such as coronary heart disease and hyperlipidemia and so on. But as aprotective factor, BMI can postpone the bone loss to some extent. Osteoporosis alsoplays an important role in the morbidity of the cardiovascular diseases and it has achance of being a predictive factor of the cardiovascular diseases.