The Clinical Analysis Of Recombinant Activated Factor â…¦a For Severe Bleeding

Objective: Clinical study of recombinant activated factor â…¦a treatment thecurative effect of severe hemorrhagic disease, emphasis on assessment of DIC andpathological obstetrics patients, analyzes the relations between platelet levels andefficacy and evaluate the safety of the drugs, to provide more reference for clinicalhemorrhagic disease.Methods: Collected from November2008to October2012in the First Hospitalof Jilin University, admitted recombinant activated factor â…¦a treatment of severebleeding disorders. Currently rFâ…¦a is still a lack of internationally acceptedstandards for the treatment of non-hemophilic bleeding disorders, most patients are inserious bleeding in the treatment of the primary disease based on traditional infusionof fresh plasma, cryoprecipitate and conventional hemostatic agents (eg, vitamin K1,hemocoagulase Etamsylate, fibrinogen, oxytocin hormone) had persistent bleeding,given recombinant activated factor â…¦90ug/kg,slow intravenous injection within2~5min. To evaluate the hemostasis effect after2h. Through blood products transfusionvolume, PT, APTT and FBG parameters to evaluate curative effect. To analysis theplatelet levels impact on the efficacy and the safety of the drug.SPSS19,0statisticalsoftware for statistical analysis.Results: Total effective rate77.59%%. Pathological obstetrics andIntraoperative bleeding efficiency was higher,100%and90%respectively. Theeffective rate treatment of patients with DIC was75%. The48h transfusion volumesignificantly reduced After treated with rFâ…¦a (P <0.0001). Platelet levels less than20x109and more than20x109/L had no obvious difference in curative effect. Lowincidence of thrombotic events.Conclusions: rFâ…¦a has high effective rate in treatingt of severe bleeding,especially for DIC, obstetric pathology. hemostasis quickly and efficiently, the fastestonset time is10minutes, the minimum effective dose is1.2mg. Plate level does notaffect hemostatic efficacy of rFâ…¦a. After treatment, the demand for blood products is significantly reduced. rFâ…¦a hemostasis less side effects, safe and reliable.