Fractional Amplitude Analysis Of Low Frequency Fluctuation In Generalized Tonic-clonic Seizure:a Resting State Functional MRI Study

Objective:To explore the whole brain activity features during the interictal with generalized tonic-clonic seizure using resting state MRI.Methods:Twenty—one GTCS individuals and21healthy control subjects, well matched in gender, age, education and handedness, were enrolled as the GTCS group and control group, respectively. A Siemens3.0T MR scanner was used to acquire all the subjects’ resting state data with GRE-EPI sequence, DPARSF software was used to process resting functional MRI data.fALFF of the two groups were calculated and compared.The correlation between fALFF and NHS3scores of GTCS was observed.Results:In comparison with the control group, the GTCS group showed reduced fALFF in cingulate gyrus, medial frontal gyrus, right opercula insulae, left supramarginal gyrus (t=4.63～-3.88, P<0.01).fALFF was increased in the cerebellum posterior lobe/cerebellar tonsil.right fusiform gyrus. inferior temporal gyrus (t=5.21～6.04,P<0.01).In addition. fALFF in the left parietal lobe, inferior parietal lobule, right fusiform gyrus, inferior temporal gyrus positively correlated with the NHS3scores of the patients(r=0.81957,P=0),while in the media) frontal gyrus. superior frontal gyrus, left insular lobe superiortemporal gyrus correlated negatively with the NHS3scores of the patients (r=-0.83067,P=0)Conclusion:GTCS patients had abnormal activity at the cingulate gyrus, medial frontal gyrus, inferior temporal gyrus, cerebellum posterior lobe.cerebellar tonsil et al,during the interictal;and these abnormal activities might be related with clinical manifestation and pathophysiology, which may help for explanation of the clinical manifestations and pathophysiological mechanisms in GTCS.