Compare The Accuracy Of The Application Of BIS And OAA/S Score In Mortitoring Sedation Depth With Different Doses Of Dexmedetomidine

Objective The dexmedetomidine set a new, potent, highly selective alpha2-adrenergic receptor agonist, imidazole derivatives. Both a strong sedative, anxiolytic, respiratory depression, stable hemodynamics role.Brain alpha2-adrenergic receptor receptor most intensive area is responsible for the mediation of arousal and sleep brainstem locus coeruleus. The sedative effect of dexmedetomidine given mainly because it is combined with the alpha2-adrenergic receptor within the brain locus coeruleus, can lead to maintaining the natural non-REM sleep.Dexmedetomidine role of alpha2-adrenergic receptor in the brain locus coeruleus, produce sedation, analgesia, while inhibition of sympathetic activity, which can effectively keep the patients in the wake state. Studies have shown that dexmedetomidine set at the same time play a good sedative effect, a protective effect on brain cells.BIS (electmencepha-logram, EEG), EEG power and frequency by fast Fourier transform and dual-band technology processing a number with0-100, the greater the value, the patients tend to be more awake. BIS can reflect the functional status of the brain cortex is considered to be sensitive, accurate assessment of the patients state of consciousness objective indicators.OAA/S score is very representative clinical sedation score a subjective evaluation method, it is primarily to determine the patient’s depth of sedation in patients with voice commands and tactile interference instruction.Our Purpose of the experiment is to compare the accuracy of the application of BIS and OAA/S score in monitoring sedation depth with different doses of dexmedetomidine.Methods60patients undergoing combined spinal-epidural anesthesia for lower limb operation(ASA grade Ⅰ-Ⅱ grade) were randomly divided into group D1.0, group D0.75and group DO.5(n=20). Male or female. Operation times were longer than2hours,. Combined spinal-epidural anesthesia were performed at L3-4, and anaesthesia effects were satisfactory. Different initial doses of dexmedetomidine (4ug/ml) were infused after the patients were well positioned. Group D1.0:1.0ug/kg dexmedetomidine was infused for10min, Group DO.75:0.75ug/kg dexmedetomidine was infused for10min, Group DO.5:0.5ug/kg dexmedetomidine was infused for10min, All of the groups were followed by continuous infusion(0.5ug/kg/h) until30min before the end of the operation. BIS and OAA/S scores were recorded before the infusion of dexmedetomidine for the basic value, and every5min after the initial infusion of dexmedetomidine.Results:1There was no significant difference between the general information of the three group of patients;2when the OAA/S scores were94(97～88)、80(86～73)、71(76～58)、55(59～48)、44(49～36);3There was a good correlation between BIS and the OAA/S scores of the three groups of patients;4When the OAA/S scores≤2,the optimal BIS value of dexmedetomidine group patients was55.Conclusion BIS can accurately monitor the sedation depth of dexmedetomidine, but it shows no advantages over the OAA/S scores.