| Objective:The aim of this study was to assess the cardioprotective effect of earlier oral nicorandil therapy in patients with acute myocardial infarction treated with primary percutaneous coronary intervention (PCI). Our study observed the effect on levels of serum creatine kinase, cardiac troponin I and early cardiac function by oral administration of nicorandil initiated before PCI.Methods:Enrolled62patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary PCI in Jinan Central Hospital affiliated to Shandong University from May2011to January2013were assigned into nicorandil group and control group randomly. All of them were pretreated with aspirin (300mg orally) and clopidogrel (600mg orally) just before PCI. Nicorandil group (n=31) took10mg nicorandil before PCI while control group (n=31) took placebo.After PCI, oral nicorandil treatment (15mg/day,three times daily) was followed in nicorandil group, and the patients in control group were given the same placebo. The other therapy was same, for example antithrombotic drugs according to guidelines. Creatine kinase(CK), CK-MB and cardiac troponin I (cTnI) were measured six hours and twelve hours after balloon angioplasty,and were compared between two groups. Left ventricular wall motion score (WMS) and left ventricular ejection fraction(LVEF) were evaluated by2-dimensional echocardiography two weeks after angioplasty.Results:(1) The levels of Creatine kinase(CK), CK-MB and cTnI in the nicorandil group were significantly lower than in the control group (P<0.05)(2) There were higher LVEF and lower left ventricular WMS in the nicorandil group than in the control group14days after PCI (P<0.05)Conclusions:Earlier oral application of nicorandil initiated before PCI affords cardioprotection, protects myocardium, decreases the infarction area, and improve early cardiac function in patients with AMI underwent primary PCI. |
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