Stage IA Non-small-cell Lung Cancer In Patients With Idiopathic Pulmonary Fibrosis Postoperative Survival Analysis

Objective：Idiopathic pulmonary fibrosis is an important factor to increase theincidence rate of lung cancer, and there are many problems in the treatment of lungcancer complicated with idiopathic pulmonary fibrosis. But for the patients’ longtermsituation after pulmonary resection operation who suffered from lung cancercomplicated with IPF has been rarely reported. The aim of this retrospective study isto determine the survival rate of the patients after pulmonary resection who had beendiagnosed as lung cancer complicated with IPF in IA stageMethods：These385cases which are used in this research are collected fromhttp://dict.youdao.com/w/上海市肺科医院/Shanghai Pulmonary Hospital. Thepatients of these cases resected their lungs after they had been diagnosed as stage IAnon-small cell lung cancer in1994to2010. According to their clinical characteristics,their chest CT, and postoperative pathological types, they are divided into two groups:28in IPF group, and357in Non-IPF groupResults：The survival rate of IPF patients is47.9%, and that of non-IPF group is83.3%.(p=0.01) Single factor analysis showed that age, gender, local resection,operation time, adenocarcinoma, IPF are important prognostic factors that influencethe survival of the patient,(P<0.05) while multiple factors analysis showed that onlyIPF is the most important prognostic factor.(P=0.002) Propensity score matchinganalysis also confirmed that IPF is the most important prognostic factor to influencethe survival of patients who has been diagnosed as stage IA non-small cell lung cancer.(P=0.014)Conclusions：IPF is an independent adverse factor to the survival of afterpulmonary resection patients who suffer from stage IA non-small cell lung cancer. Sodoctors should be deliberately decide whether they should perform operations on the patients who have a merger of IPF IA stage non-small cell lung cancer.