Expression Of TRIM29, P53and β-catenin In Non-small Cell Lung Cancer And Its Clinical Pathologial Significance

Objective: To investigate the relationship between TRIM29expression and clinicalpathology and prognosis of non-small cell lung cancer(NSCLC).Methods: The TRIM29, P53and β-catenin expression of carcinomas and adjacentnormal tissues in317cases of NSCLC treated by surgery was detected by theimmunohistoehemical method． The relationship between P53, β-catenin,clinical-pathologial data and TRIM29were analyzed by χ2test and Spearman’s rankcorrelation analysis. Both the Kaplan–Meier method and Log-Rank test were used forsingle variant analysis, and a Cox model was used to analyze relationships betweensurvival rates and multiple variables. P<0.05were considered to be significant.Results (1) TRIM29expression in cancer tissues in317cases of NSCLC wassignificantly higher than in adjacent normal tissues and (2) TRIM29expression inNSCLC was positively correlated with abnormal expression of β-catenin, histologicalgrade, TNM stage and lymph node metastasis.(3)The TRIM29expression in squamouscell carcinoma(SC) and adenocarcinoma(AC) was significantly different, particularly inpoorly differentiated tumor, TRIM29expression in the majority of SC was stronglypositive or positive (97.6%), while AC was significantly weaker and the majority ofthem was negative or weakly positive (73.5%) and no strong positive.(4) Mutant p53expression and abnormal expression of β-catenin protein showed significant correlationin NSCLC.(5)High-expression of TRIM29and high clinical stage were independentprognostic indicators in SC while (6)Only high clinical stage in AC, though expressionof TRIM29were significantly related to postoperative survival analyzed by log-ranktest was independent prognosis index (p=0.007).Conclusion: TRIM29could play an important role on the histological identificationof NSCLC especially the identification of poorly differentiated SC and AC with thereference value for clinical treatment to improve the accuracy of Pathological diagnosis and postoperative assessment. TRIM29, P53and β-catenin participate in thedevelopment of NSCLC.