Two Alkyl Tin Acyl Hydrazone Class Preparation, Characterization And Properties Of Schiff Base Derivatives Research

Acylhydrazone Schiff bases have wildly application in the fields of agriculture, medicine,materials, and analytical reagents because of its unique structural features, strong coordinationability, excellent coordination forms, and high activity of biological drugs. Due to novelstructures and various coordination models, fine biological activity, the derivatives of organotinwith acylhydrazone Schiff base has become a crazy area for researchers. In the thesis,51newdiorganotin derivatives, derived from diorganotin oxides or chlorides and acylhydrazone classSchiff bases, were synthesized and characterized by means of element analysis, IR, NMR, X-raysingle crystal diffraction. The crystal structures of11compounds were resolved. Theantibacterial activities of the typical compounds against Escherichia coli were determined. Therelationship between the structure and activity was discussed preliminarily.1.25acylhydrazone Schiff bases weresynthesized by the reaction of phenylglycolic hydrazide, L-pyroglutamic hydrazide,p-nitroaryloxyacetyl hydrazide and N,3-dimethyl-5-(methylmercapto)-4-pyrazole-formylhydrazide with salicylic aldehyde, benzoyl acetone, pyroracemic acid, respectively. Theirstructures were characterized by element analysis, IR, NMR, X-ray single crystal diffraction, andthe crystal structures ofere determined.2.51new derivatives of diorganotin, R2SnL, were synthesized by the reaction of the abovementioned Schiff base with dialkyltin oxides or dialkyltin chorides and characterized by meansof element analysis, IR, NMR, X-ray single crystal diffraction. The crystal structures ofwere measured. The tin atom is penta-coordinated andpossesses a diatorted trigonal bipyramidal geometry. The five coordination atoms come from twocarbon atoms of alkyls, oxygen atom of enolization HO-C=N, oxygen atom of carboxylate (orphenolic hydroxyl group), and the imino nitrogen atom. The molecules of the derivatives exist in monomeric form or dimer or polymeric structure formed by the intermolecular Sn···O weakactions3. The antibacterial activities of, H2L22and, and against Escherichia coli were determined by using microcalorimetry method.The results show that these compounds all have antibacterial activity. The inhibitory effect oforganotin derivatives is superior to the corresponding ligand, and different substituent-groups onthe tin have different effects, and the order is Bu>Ph> Me. The antibacterial activity of somederivatives is better than that of antimicrobial drugs on the market today. This work provides anexperimental basis for the design and synthesis of more efficient anti-bacterial drugs.