- Replace - 2-2 Oxazoline New Reduction Reaction Research

As an important kind organic compound,2-oxazolines have attracted a wide range of interests of synthetic and medicinal chemists. To date, several synthesis methods of2-oxazolines have been reported, however, only a few reports involve the reduction reaction of2-oxazolines in the literature, in this thesis the reduction reaction of2-substituted-2-oxazolines under NaBH4system is systematically studied the first.Part â… :Ten2-substituented-2-oxazolines including two2-alkyl-2-oxazolines and eight2-aryl-2-oxazolines were prepared under suitable catalytic addition from ethanolamine and the corresponding nitriles. Among these2-substituented-2-oxazolines,2-methyl and2-benzyl-2-oxazolines were synthetised using ZnCl2as catalysts;2-phenyl-2-oxazoline was synthetised using Cd(CH3COO)2as catalysts;2-p-chlorophenyl,2-o-chlorophenyl,2-o-Methylphenyl,2-m-Methylphenyl,2-(2-pyridyl),2-(3-pyridyl) and2-(4-pyridyl)-2-oxazolines were synthetised using ZrOCl2as catalysts. In addition, the chemical structures of2-substituented-2-oxazolines were identified and confirmed by IR, GC-MS and ESI-MS.Part â…¡:The reduction reaction of the ten2-substituted-2-oxazolines was systematically studied under NaBH4system. Reduction systems in this work included NaBH4system, NaBH4-HC1system. NaBH4-I2system. NaBH4-CoCl2system, NaBH4-CeCl3system, NaBH4-ZnCl2system and NaBH4-TiCl4system. The chemical structures of the products were identified and confirmed by ESI-MS,:H NMR and13C NMR. The experiment results present that the ten2-substituted-2-oxazolines opened their rings under these seven reduction systems, producing the corresponding N-substituted ethanolamines. At the same time, the effects of seven reduction systems on2-substituted-2-oxazolines reduction reactions and2-substituent group of2-substituented-2-oxazolines on reduction reactions under the same reduction system were studied in this work. The results indicate that NaBH4-12system shows the best reduction effect among these seven reduction systems, and the yields of2-alkyl-2-oxazolines are higher than that of2-aryl-2-oxazolines under the same reduction systems.Therefore, in this work it is firstly covered that the2-substituted-2-oxazolines opened their rings under NaBH4systems, producing the corresponding N-substituted ethanolamines, in addition, a novel method for synthesis of N-substituted ethanolamines was provided.