O Cut That The Analogues Of N - (2 - Pyrimidine Methyl) - 2 - Amino - 4 - (3 - Chloro - 4 - Methoxy Benzyl Amine) - 5 - Pyrimidine Formamide Synthesis

N-(2-Methyl-pyrimidine)-4-(3-chloro-4-methoxybenzylamino)-2-amino-5-pyrimi-dine carboxamide was designed and synthesized on the basis of literature research. The compound is a potential of phosphodiesterase inhibitors.After through process optimization of the syntheric route, including the solvent used for the reaction and workup.2-ethoxycarbonyl vinyl diethyl malonate and S-methyl isothiourea sulfate were the starting materials, the target product was obtained by cyclization, chlorination, nucleophilic aromatic substitution7-steps reaction with the total yield9.9%. The optimized route for a large number of syntheric in the laboratory can meet hundreds of grams of synthetic needs.This thesis provides a reliable process route for alpha non-analogues:4-(3-chloro-4-methoxy-benzylamino)-2-amino-N-(2-pyrimidine methyl)-5-pyrimidine A ceramide synthesis, and provides a guarantee for further bioassay.