| Objective:This experiment to study the underlying mechanism of acupuncture and moxibustion for simple obesity by investigating the influence the relevant indexes in nutritional obese rats, including the body weight, the weight differences between before and after treatment, the serum level of glucose, insulin and adiponectin.Methods:60male SD rats were randomly divided into two groups:10rats in the blank control group and50rats in the model group. During the period modeling, the blank control group rats were fed with normal diet, the model group rats were fed with high fat diet. After nine weeks, the rat weight of the model group is20%heavier than the average weight of the blank control group, it means the establishment of model was successed. There are24rats were made model success and randomly divided them into three groups:8rats in the model group,8rats in the moxibustion group,8rats in the acupuncture group. The treatment duration was20days, the rats of each groups were fed with normal diet, free feeding and drinking. Rats in blank control group and the model group were only fixed; Rats in moxibustion group and acupuncture group were received treatment at "Guan yuan" acupuncture point. The treatment had been conducted for15min daily for20days. During the modeling and treatment period, weighing the weight of the rats in each group, after the end of the experiment, fats aroud perirenal area and epididymides area were seperated and weigh there weight. And the level of blood serum Glucose,Insulin,Adiponectin factors were measured.Results:(1) The body weight:During the period of modeling, the weight of the model group is20%heavier than the average of blank control group, it means the establishment of model was successful. Before treatment, no significant difference among model group, moxibustion group, acupuncture group (P>0.05). After treatment,the weight of the model group, the moxibustion group, the acupuncture group considerably higher than the blank group, with a significant difference (P<0.05). Compared with the model group the moxibustion group and the acupuncture group significantly reduced, their difference was also statistically significant (P<0.05). No significant difference between the moxibustion group and the acupuncture group (P>0.05). From the weight differences on rats between before and after treatment, the moxibustion group and the acupuncture group was significantly lower than the blank control group and the model group, with significant differences (P <0.05).(2) Wet weight of fat:Compared with the blank control group, the wet weight of the area perirenal and epididymides area fat higher in the model group, the moxibustion group, the acupuncture group with significant difference (P<0.05). After treatment, the wet weight of the fat in moxibustion group and acupuncture group was decreased, compared with the model group, there was a significant statistical difference (P<0.05). No significant difference between the moxibustion group and the acupuncture group (P>0.05).(3) Glucose:Compared with the blank control group, the serum level of glucose significantly increased in the model group, the moxibustion group, the acupuncture group, and there was a significant difference (P<0.05). The glucose level in the moxibustion group and the acupuncture group were significantly lower than that of the model group (P<0.05), with the blank control group without statistical significance (P>0.05). No significant difference between the moxibustion group and the acupuncture group (P>0.05)(4) Insulin:Compared with the blank control group, the serum level of insulin and insulin resistance index significantly increased in the model group, the moxibustion group, the acupuncture group, with a significant difference (P<0.05). The serum level of insulin the moxibustion group and acupuncture group were significantly lower than that of the model group (P <0.05), with the blank control group without statistical significance (P>0.05). No significant difference between the moxibustion group and the acupuncture group (P>0.05)(5) Adiponectin:Compared with the blank control group, the serum level of adiponectin significantly decreased in the model group, the moxibustion group, the acupuncture group, and there was a significant difference (P <0.05).After the treatment, the serum adiponectin contents of the moxibustion group and the acupuncture group were considerably higher than that of the model group (P<0.05), with the blank control group without statistical significance (P>0.05). No significant difference between the moxibustion group and acupuncture group (P>0.05)Conclusion:1. Acupuncture and moxibustion can lower the body weight of nutritional abese rats, which is effective in reducing body.2. Acupuncture and moxibustion can decrease the serum level of glucose, insulin and the insulin resistance level of the nutritional abese rats, through that glycometabolism disorder in body is regulated, which can achieve reducing body.3. Acupuncture and moxibustion treatment can raise the serum level of adiponectin in nutritional obese rats, which may contribute to its effect in reducing body. |
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