Three Female Breast Cancer In The Neoadjuvant Chemotherapy Sensitivity Of Meta Analysis

Purpose：Neoadjuvant chemotherapy (NAC) was increasingly used as a systemictherapy for triple-negative breast cancer(TNBC). The pathological completeresponse(pCR) rates of NAC in TNBC were higher than other types of breast cancerwith fluctuate data. The meta-analysis was conducted to contrast the pCR ratesof NAC in TNBC, non-TNBC and HER2-positive tumors. The prognostic function ofsome clinicopathological parameters were also examined in the pCR rates of NACfor TNBC.Material and method：Studies were selected from the PubMed database and CochraneCollaboration Library. pCR rates were collected in groups of TNBC, non-TNBC andHER2-positive tumors. The relavant parameters to pCR rates in TNBC group werealso recorded.Results：The analysis included22studies with7168patients, the aggregatepercentage of pCR was29.5%in TNBC group, which is17.7%higher compared tonon-TNBC. The summary relative risk(RR) for pCR rate of TNBC group with thatof non-TNBC group was2.55(95%CI:2.31–2.83). No obvious statisticalheterogeneity and publication bias was detected. The association of lymph nodesmetastasis, Ki-67expression, p53expression and CK5/6expression with pCR rateof TNBC was also investigated in the analysis，and the odds ratios(OR) were0.50(95%CI:0.26–0.95),9.87(95%CI:3.53–27.62),1.17(95%CI:0.45–3.07)and0.53(95%CI:0.09–3.09) respectively.Conclusion： This meta-analysis demonstrates that NAC shows a higherchemosensitivity for TNBC than other types of breast cancer. Ki-67expressionand lymph nodes metastasis were predictors of pCR rate for TNBC in NAC, whilep53and CK5/6expression could not be confirmed for the prognostic function.