Word Couplet Navigation Training Method For Chronic Non Fluent Aphasia Speech Function Restore Magnetoencephalography Does Research

Objective：To explore brain neural network activities during picture naming and the relations ofthem to impaired language abilities in patients with chronic non-fluent aphasia.Method：Five patients with chronic non-fluent aphasia and five age-, gender-andeducation-matched healthy controls were recruited in this study. All behavioralperformance was assessed with western aphasia battery (WAB) and brain languageprocessing during picture naming was detected with magnetoencephalography(MEG).Result：The magnitudes of Broca’s area activation were significantly lower in patient groupthan in control group (p<0.05) during400ms-600ms of picture naming by comparisonof picture naming-related regions of interest(ROIs),while the magnitudes of activationin Broca-homologue area, Wernicke-homologue area and inferior parietal lobule ofright hemisphere were significantly higher in patient group than in control group(p<0.05). There were significantly correlations between aphasia quotient(AQ) andbrain activation in Broca-homologue area in aphasia patients （r=0.886, n=5,p=0.045）. Conclusion：Neural network activities of right hemisphere during speech put-out preparation arewidely activated in patients with chronic non-fluent aphasia, which is suggestivelyrelated to low levels of spontaneous compensatory for language function after braindamage. Objective:To study laterality changes of language activity after word association navigationtraining (WANT) in chronic non-fluent aphasia for the further exploration of possiblemechanism of language functional recovery.Method:Five patients with chronic non-fluent aphasia were recruited in this study. Thebehavioral assessments with picture naming task, Western Aphasia Battery (WAB),Standard Language Test of Aphasia (SLTA), and Mini-Communicative Activity Log(Mini-CAL) were executed before and after WANT. The language-specific activitiesduring a delayed picture naming task before and after WANT were obtained by MEG.Laterality of every region of interest (ROI) activity was compared before and afterWANT.Results:The correct number of picture naming, AQ,“repetition” and “naming” of WAB,“listening” and “speaking” of SLTA, and Mini-CAL were significantly improved aftertraining in5patients. Before training, picture naming-related activities of rightBroca-homologue area were significantly stronger than that of Broca’s area (p<0.05) during275-400ms and400ms-600ms of picture naming. After training, thesedifferences between right Broca-homologue area and Broca’s area were not observed(p>0.05). Laterality index (LI) in Broca’s area was significantly increased aftertraining and the increase of LI was significantly correlated with the improvement oftrained picture naming ability（r=0.884, n=5, p=0.0466）.Conclusion:Improvement of speech function may be related to left-lateralized Broca’s areaactivity induced by WANT and LI may be a more sensitive predictor of languagerecovery in chronic non-fluent aphasia.