Based On Literature Review And Subacute Cough Syndrome Characteristics Of Data Mining Research

Objective1To obtain the distribution of syndromes, syndrome elements and symptoms of sub-acute cough by analyzing the relevant literature in the recent decade, and to provide the basis for clinical study.2To comprehend the TCM syndrome characteristics of sub-acute cough by means of clinical study, and to discuss the relation between the frequent syndrome elements and symptoms of sub-acute cough by applying statistical analysis to the information of TCM syndromes, syndrome elements and symptoms.Methods1Literature studyLiterature about sub-acute cough in the recent decade was searched and analyzed, and information extraction form was founded. SPSS17.0statistical software was adopted to analyze the frequency and times on the information of TCM syndromes, syndrome elements and symptoms.2Clinical studyThe case information was collected and put into the clinical information collection and analysis system based on the distribution of TCM syndromes, syndrome elements and symptoms obtained from the literature study. Observational study methods of multi-central and open were adopted and276cases were collected. SPSS17.0statistical software was adopted to analyze the information of TCM syndromes, syndrome elements and symptoms by applying ratio analysis, correlation analysis and Logistic regression analysis.Results1Literature studyThere were72kinds of syndromes after standardization in the collected263articles, and there were6common kinds of syndromes including wind-cold attacking the lung syndrome, wind restraining the lung syndrome, phlegm-heat obstructing the lung syndrome, lung qi deficiency syndrome, phlegm-dampness obstructing the lung syndrome and wind-heat attacking the lung syndrome.There were26kinds of syndrome elements after extraction of the literature, and the main syndrome element on disease location was the lung, after which were the spleen, the liver and the kidney; the main syndrome element on disease characteristic was wind, after which were heat, qi deficiency, phlegm, yin deficiency, cold and dryness.There were99kinds of symptoms after standardization (not including the tongue and the pulse), the symptoms on top including dry cough, paroxysmal cough, little sputum, white sputum, sticky sputum, thin sputum, chest tightness, itchy throat, dry throat, spontaneous sweating, dry mouth, fatigue and loss of appetite; there were31kinds of tongue characteristics, the common ones including red tongue, pale tongue, pale-red tongue, white coating, yellow coating and greasy coating; there were17kinds of pulse conditions, the common ones including thready pulse, rapid pulse, floating pulse, wiry pulse and slippery pulse.2Clinical epidemiology studyThere were4kinds of common TCM syndromes, including lung qi deficiency syndrome, phlegm-dampness obstructing the lung syndrome, lung qi-yin deficiency syndrome and wind restraining the lung syndrome.The main syndrome element on disease location was the lung, after which was the spleen; the main syndrome element on disease characteristic was qi deficiency, after which were heat, phlegm, yin deficiency, wind and dryness.There were42kinds of common symptoms, including white sputum, yellow sputum, cough without sputum, thin sputum, thick sputum, little sputum, much sputum, paroxysmal cough, coughing with a heavy sound, coughing with a clear sound, cough aggravating with no significant time difference, cough aggravating at night, cough aggravating in the morning, cough aggravating at day time, cough induced by cold wind, cough induced by fumes, cough induced by odor, cough induced by too much talking, hoarse voice, chest tightness, short of breath, asthma while moving, itchy throat, sore throat, pharyngeal foreign body sensation, dry mouth, thirsty and drinking much, afraid of cold, afraid of wind, fatigue, easy to catch a cold, stuffy nose, sneezing, watery discharge, spontaneous sweating, loose stool, dry stool, abdominal distension, feeling hot in the heart, palms and soles, restlessness, insomnia and dreaming often, weakness in the lower back and knees occasionally.There were15kinds of common tongue characteristics and pulse conditions, the former including dark red tongue, pale-dark tongue, bright red tongue, white coating, yellow coating, thin coating, thick coating, greasy coating, dry coating, enlarged and tooth-marked tongue; the latter including thready pulse, deep pulse, slippery pulse, wiry pulse and weak pulse.3Correlation analysisBy correlation analysis, the syndrome element qi deficiency was positively relevant with chest tightness, short of breath and itchy throat, negatively relevant with yellow sputum and coughing with a clear sound; the syndrome element heat was positively relevant with yellow sputum, thick sputum, much sputum, cough induced by fumes and restlessness; the syndrome clement phlegm was positively relevant with yellow sputum, thick sputum, much sputum, dry stool and abdominal distension, negatively relevant with cough without sputum and cough induced by cold wind; the syndrome element yin deficiency was positively relevant with cough aggravating in the morning, chest tightness, short of breath, thirsty and drinking much, afraid of cold, afraid of wind, feeling hot in the heart, palms and soles and restlessness, negatively relevant with cough aggravating at night and dry stool; the syndrome element wind was positively relevant with coughing with a clear sound, cough induced by cold wind and too much talking.4Regression analysisBy Logistic regression analysis, white sputum, cough without sputum, short of breath and itchy throat were significant in judging the syndrome element qi deficiency, and coughing with a clear sound was negatively significant; thick sputum, cough induced by fumes and restlessness were significant in judging the syndrome element heat, and cough aggravating at day time was negatively significant; much sputum and dry stool were significant in judging the syndrome element phlegm, and cough without sputum and cough induced by cold wind were negatively significant; cough aggravating with no significant time difference, cough aggravating in the morning, short of breath, thirsty and drinking much and feeling hot in the heart, palms and soles were significant in judging the syndrome element yin deficiency, and dry stool was negatively significant; coughing with a clear sound and cough induced by cold wind were significant in judging the syndrome element wind.Conclusion1The distribution law of syndromes, syndrome elements and symptoms of sub-acute cough has been obtained from literature study, and the basic status of the study on this disease has been reflected objectively.2The distribution situation of syndromes, syndrome elements and symptoms of sub-acute cough patients has been obtained from observational clinical study methods of multi-central and open, basically consistent with the results of literature study. Correlation analysis and regression analysis has been applied to discuss the relation between the frequent syndrome elements and symptoms of sub-acute cough and to provide references for clinical syndrome differentiation.