Tomifying Qi And Blood And Bone Marrow Fertile Bcr/abl Negative Tumor Patients' Clinical Curative Effect Analysis

Overview:myeloproliferative neoplasms (MPN) is a group of relatively mature differentiated neoplastic diseases of the hematopoietic stem cells, expressed as a series or system of bone marrow cells continue to clonal proliferation. Polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF) is the MPN of BCR/ABL-negative, respectively polycythemia, thrombocytosis and myelofibrosis, duration the main manifestations of abnormal blood count, thromboembolism, bleeding, liver and spleen enlargement, in patients with advanced IMF also pancytopenia. Among the diseases can be transformed into each other, can also be developed into acute leukemia. Western medicine for PV, ET and IMF treatment mainly hydroxyurea, busulfan chemotherapy to inhibit the proliferation of bone marrow, but long-term use can promote bone marrow fibrosis, and lead to the occurrence of leukemia and other malignancies. Interferon for the treatment of MPN non-induced leukemia and bone marrow fibrosis, but its treatment often lead to fever, muscle and joint pain and other adverse reactions, some patients can not tolerate the withdrawal. Splenectomy often relieve the symptoms of patients with mechanical pressure, but splenectomy related mortality is high, can accelerate liver and extreme thrombocytosis. Phlebotomy is the basic method of treatment of PV, but can cause rebound elevated red blood cells and platelet count, and can induce or promote thrombosis. Therefore, the search efficiency and low toxicity, long-term control of the disease and slow the progression of the disease, treatment has important clinical value. The spirit of Chinese medicine treatment for different diseases, the same disease with different treatment principle, our department has long been replenishing Qi and nourishing and activating blood on contracting parties as basic treatment of myeloproliferative neoplasms and achieved good effect, with a non-toxic side effects, the advantages of long-term control of the disease.Objective:To evaluate the effect of replenishing Qi and nourishmg and activating blood on the treatment of myeloproliferative neoplasms.Methods:A retrospective analysis of55patients with complete treatment data records for more than6months of our department BCR/ABL-negative myeloproliferative neoplasms patients, divided into three groups:â‘ polycythemia vera15cases;â‘¡essential thrombocythemia24cases;â‘¢idiopathic myelofibrosis16cases. Chinese medicine treatment were given our department replenishing Qi and nourishing and activating blood contracting parties mainly, and supplemented by Western symptomatic and supportive treatment in all patients with serious illness. Specifically:our department replenishing Qi and nourishing and activating blood on contracting parties, on this basis, with the addition and subtraction cards continued to take him for the medical changed to the same prescription made Chinese medicine Miwan of drug taking in January after each pill9g each time a pill,2times a day. Record changes in blood of patients with improvement of symptoms, three groups of patients before and after treatment were compared before and after treatment, and the effects were compared between the three groups.Results:The PV group after treatment, the number of red blood cells, hemoglobin, hematocrit compared with before treatment, there are significant differences, and white blood cells, platelets no significant difference. ET group after treatment, platelets, white blood cell count decreased significantly compared with the previous, the statistical significant difference, and no significant difference in hemoglobin before treatment. Hemoglobin compared with the previous the IMF group patients after treatment significantly increased, the statistical significant difference, and white blood cells and platelet count have no significant difference in the test. Three groups before and after treatment symptom scores compared were significantly different. Efficacy:PV patients markedly effective in8cases,4cases improved and ineffective in3, the total effective rate was80%. ET patients markedly effective in15cases,5cases improved and ineffective in4, the total effective rate was83.3%.IMF patients markedly effective in5cases,6cases improved and ineffective in5, the total effective rate was68.8%.Effective rate in the ET group> PV group> IMF group between the three groups efficacy of pairwise comparisons, statistical tests was no significant difference.Conclusion:â‘ the use of Replenishing Qi and nourishing and activating blood treatment of myeloproliferative neoplasms, three sets of clinical symptoms were significantly improved, a significant difference before and after treatment by the statistical test; three sets of clinical comparison of the efficacy of the ET group than the PV group and the IMF group, the PV group than the IMF group, but no significant difference considering the possibility of its own characteristics and disease-related.â‘¡Chinese medicine treatment the myeloproliferative neoplasms can be achieved to improve symptoms, long-term control of the disease and low side effects.