| Malignant ascites is one of the common late complications of tumor patients, mostly secondary to ovarian cancer, breast cancer, colon cancer, stomach cancer, liver cancer, pancreatic cancer and other diseases, and the free Survival is about only a few weeks to a few months, average survival time is about4months; year survival rate is less than10percent. There are some difficulties in the treatment, also has the feature of stubborn state of an illness, large effusion, easy recurring. Western medical treatment is taken for treatment of the primary disease, such as radiotherapy and chemotherapy, and diuretic, supplement albumin, ascites drainage. These methods can solve some problems, but still a part of malignant ascites can not be effectively alleviated. Moreover, these methods are inadequate, easily cause adverse reactions. For example:diuretics can not completely relieve symptoms, even lead to hypokalemia and electrolyte imbalance, also, a large number of ascites drainage can easily result in hypoproteinemia, Each pumping volume is limited to be repeated suction, and it is difficult to completely drainage d. In addition, repeated paracentesis, not only caused by the patient’s pain, and also likely to cause increased risk of complications of such as subcutaneous cancer planting and infection, which seriously affect the life quality of patients. The ascites patients often feel bloating and the decoction application is always restricted. Therefore, to find an effective and easily accepted therapy is imperative. In recent years, Chinese medicine external treatment of malignant ascites treatment achieved more satisfactory results. External treatment of skin penetration of drugs through dressing, paste, coating, rub, smoked, steamed, wash, bath, to through the epidermal barrier. Because of the90percent vascular is sub-dermal, can quickly reach disease target internal organs and play a therapeutic role.Objective:To analyze the efficacy of TCM external treatment of malignant ascites comprehensively, also to summarize clinical approaches with significant effect and easy operations. Methods:In this prospective study, we analyzed the status of the Third Affiliated Hospital of Beijing University of Chinese Medicine Oncology hospitalized patients with malignant ascites. We selected30eligible patients with malignant ascites, and determine the efficacy by comparing before and after treatment in patients with abdominal circumference changes by using our department experience prescriptions "Wen Yang Xiao Shui San" after five days. Take Shenque Xue to paste the central point of the adhesive point washed and dry, and make the drug powder into a paste with warm water and mix thoroughly, placed25×31cm dressings central area, gauze expand coverage, medicines range from about8×10cm, drugs thickness about2mm, around the tape securely gauze affixed to the abdomen, every4-6hours to remove the dressings and drugs. At the same time, the K.PS score, the symptom score comparison is compared. Results:In terms of abdominal circumference changes: abdominal circumference decreased2.3±1.58cm in before and after treatment. The difference was statistically significant (P<0.05),15cases in ascites subsided grade Ⅲ, which is50%of the efficient; Improvement of quality of life:Karnofsky score increased:7.67±6.26after treatment, the difference was statistically significant (P<0.05); In terms of symptom improvement:According to three of the most obvious symptoms of bloating, abdominal pain, difficulty breathing to score, found that after treatment symptom score decreased by an average of2.37+1.30, the difference was statistically significant (P<0.05), Among them, the three main symptoms before and after treatment, making respectively pair wise comparison showed that Three groups were<0.05and the difference was statistically significant; In terms of safety was100.00%. which compared liver and kidney function, ECG, routine blood test and other safety indicators, also rash, itching, skin ulceration, and other adverse reactions before and after treatment; Comprehensive treatment satisfaction:The satisfaction rate was70.00%. The most obvious onset time was2.40±0.89days. Conclusion:External application of Chinese medicine treatment in malignant ascites can effectively reduce abdominal circumference, which can achieve the purpose of reducing ascites, and improve the patient’s symptoms. At the same time, the use of the prescription lets patients get better physical condition and quality of life. The TCM external treatment has exact effect, with no significant adverse reactions. The treatment of herbal external application on abdominal wall fully reflects the feature of "simple. easy, effective, cheap" and "External treatment is internal treatment. External medicine is Internal medicine, just different methods"... |
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