Coronary Heart Disease (chd) In Chronic Heart Failure Syndromes And Plasma Gdf - 15, Tgf - Beta 1 Level Correlation Studies

Objective:This paper aimed to study the correlation between the different Traditional Chinese Medicine (TCM) syndromes of Chronic Heart Failure (CHF) with Coronary Heart Disease (CHD) and the serum level of Growth Differentiation Factor15(GDF-15) and Transforming Growth Factor-beta1(TGF-β1), and to explore the TCM syndromes objective quantitative index, and provide objective reliance for syndrome differentiation, and guide the syndrome differentiation and treatments in TCM clinical practice.Methods:Patients with CHD were enrolled from the Department of Cardiovascular of Guang’an Men hospital from October2012to February2013.62enrolled patients with CHF were distributed in the study group and were evaluated by doctor in charge according to the NYHA functional class as well as the TCM syndrome differentiation.10enrolled CHD patients without CHF were in the control group. All the serum samples of the enrolled patients were tested by Enzyme-Linked Immunosorbent Assay (Elisa) to determine the level of GDF-15and TGF-β1, and Chemiluminescence Immunoassay (CLIA) to test the level of NT-proBNP. The collected data was processed and analyzed by the statistical analysis software.Results:In the study group,22patients were in the NYHA functional class Ⅱ, and30in the NYHA functional class Ⅲ and10in the NYHA functional class Ⅳ. According to the TCM syndrome differentiation,10patients were characterized in the Heart and Lung Qi deficiency syndrome group, and20in the Qi and Yin deficiency syndrome group, and19in the Qi deficiency and Blood stagnation syndrome group, and13in the Yang deficiency and Water diffusion syndrome. According to the statistical analysis, the serum level of GDF-15and NT-proBNP in the study group were higher than the control group and the statistical analysis showed a significant difference. The serum level of TGF-β1in the study group was lower than the control group and the statistical analysis showed a significant difference.The increase in the level of serum GDF-15and NT-proBNP was linked to the increase of the NYHA functional class, and the statistical analysis showed a significant difference. The scrum level of TGF-β1in the study group showed a statistical difference in NHYA functional classes. In the study of TCM syndrome differentiation, the serum level of GDF-15decreased as follows:Yang deficiency and Water diffusion syndrome group, Qi deficiency and Blood stagnation syndrome group, Qi deficiency and Yin deficiency syndrome group, Heart and Lung Qi deficiency syndrome group, the control group. The serum level of TGF-β1decreased as follows:The control group, Qi and Yin deficiency syndrome group, Heart and Lung Qi deficiency syndrome group, Qi deficiency and Blood stagnation group, Yang deficiency and Water diffusion syndrome group. The serum level of NT-proBNP decreased as follows:Yang deficiency and Water diffusion syndrome group, Qi deficiency and Blood stagnation syndrome group, Qi deficiency and Yin deficiency syndrome group, Heart and Lung qi deficiency syndrome group, the control group.Conclusion:1The serum level of GDF-15in the study group was higher (P<0.05) than the control group; The serum level of GDF-15showed a positive correlation with NT-proBNP, and increased with the rise NHYA functional class. Both the GDF-15and NT-proBNP can be used as diagnostic indicators of CHF.2The serum level of TGF-β1was lower than the control group, and showed the tendency of decreasing with the rise of the NHYA functional class.3The serum level of GDF-15among the TCM syndrome groups and the control group decreased as follows:Yang deficiency and Water diffusion syndrome group, Qi deficiency and Blood stagnation syndrome group, Qi deficiency and Yin deficiency syndrome group, Heart and Lung Qi deficiency syndrome group, the control group.4The serum levels of TGF-(31among the TCM syndrome groups and the control group decreased as follows:The control group, Qi and Yin deficiency syndrome group, Heart and Lung Qi deficiency syndrome group, Qi deficiency and Blood stagnation syndrome group, Yang deficiency and Water diffusion syndrome group.