Studies On Cycloaddition Reactions Involving Methyleneindolinone

This dissertation describes the cycloaddition reaction involvingmethyleneindolinones. Briefly describe as followed:1. Multicomponent cycloaddition with isocyanide,2,3-butadienoate andmethyleneindolinoneMethyleneindolinone can react smoothly with isocyanide and2,3-butadienoate,thus providing a new strategy for the syntheses of a series of structurally complexspirocycles. Further investigation shows that the present method is applicable to abroad scope of substrates. In addition, high regional selectivity is also observed duringthis process. At the same time, we have also discovered a new four-componentcycloaddition, which involves tandem triple Michael addition/cyclization process.2. Cycloaddition reaction with aryne and methyleneindolinoneCycloaddition reactions of methyleneindolinones and arynes can generatestructurally unusual naphtho-fused oxindoles. The present strategy opens a convergentand powerful pathway for the construction of polycyclic skeletons. Furthermore, thismethod is also distinguished by its convenient experimental setup, high yield andatom economy.