The Synthesis Of The Bioactive Glass And Study On The Properties

Since the discovery of45S5bioactive glasses by Hench, the bioactive glasses havebeenconsidered as a promising alternative as materials toregenerate,repair and replace theskeletal system. Bioactive glasses have a widely recognized ability to foster the growth ofbone cells, and to bond strongly with hard and soft tissues.Compared with the conventional melt method, the bioglass prepared by sol-gel methodhas a higher surface area and porous structure,and shows a higher bioactivity; meanwhile, bychanging the composition or process parameters,the structure and chemical properties ofthebioactive glass are able to make adjustments in a wide range,whichmake it possible tomeetdifferentneeds by controlling the glass composition and degradation rate of the composition.In this work, representative45S5,58S and70S bioactive glass was successfully preparedby the sol-gel method, and magnesium, zinc and strontium elements wereintroduced into thebioactive glasses basedon58S to research the effect on the crystallization, biodegradability,porosity as well as bioactivity. In addition, the porous elastomer scaffolds were preparedwithbioglass powder and PDMS viapore-formingagent.The detailed contents are as follows:The45S5,58S and70S bioglass have been prepared by sol-gel method,their mineralizedperformancesin a simulated body fluid were compared through using XRD and SEM analysis.The corresponding results show that: the apatitedeposited on the surface of the three samplesin SBF, however, themineralization and degradation rate of the45S5which contained sodiumelement was more significant. Incorporation of the sodium can accelerate the rate of release oftheions and can promote the crystallization of the glass.The bioglass doped with magnesium, zinc and strontium was obtained by sol-gel method,and studied the influence of the doping element on the biological properties of glass. Resultsshowed that the incorporation of the magnesium and zinc would strengthen the glass networkstructure, promote the crystallization of the glass and reduce the rate of apatite forming. Whilethe incorporation of strontium would weaken the glass network structure,and could promotethe formation of the crystalline phase andthe deposition of apatite.A multi-scale microporous three dimensional porous elasticscaffold was prepared withthe paraffin sphere as a pore-forming agent by the pore forming method.Thein vitro activitytests proved the scaffold to be a good biological activity.It’s expected as a carrier to study cell mechanical response.