Taohongsiwu Granules Production Processes Optimization And Quality Control Study

Objective: Tao Hong Si Wu Tang (TSD), a famous Chinese complex prescription, hasbeen widely used for gynecological and obstetrical purposes for a long time.In thisstudy, we optimize TSG supercritical extraction process and select the the bestprescription of TSG. Build a Ultra-high pressure liquid chromatography (UPLC)method to determine the content of the four major effective ingredient of TSG in thesame time. Establish the quality control standards of TSG to provide a reference for theactual production.Methods: Use analysis of variance, comprehensive considerate the influence of variousfactors on the temperature, pressure, ratio of entrainer to established the optimalconditions of SFE. Judge the multiple score to choose the best production prescription ofTaohongsiwu granules.Use Ultra-high pressure liquid chromatography (UPLC) todetermine the content of the four major effective ingredient of TSG in the same time.Use SFE S to produce the TSG granules. Reference Ph.C to develop quality controlstandards of TSG granules, and examine the stability of the granulesResult: Using SFE product the TSD granules and determine the optimal conditions: temperature50°C, pressure of110bar, the proportion of entrainer5%by orthogonal experimental design.Judging from the multiple score, the best preparation prescription drugs dry extract powder:powdered sugar: dextrin (1:4.5:0.5). Use Ultra-high pressure liquid chromatography (UPLC)can determine the content of the four major effective ingredient of TSG in the sametime. Establish the quality standards of TSG. TSG is stable under dry conditions at roomtemperature, protected from light.Conclusion: The optimal conditions of SFE: temperature50°C, pressure of110bar, theproportion of entrainer5%. The best preparation prescription drugs dry extract powder: powdered sugar: dextrin (1:4.5:0.5). Build the Ultra-high pressure liquid chromatography (UPLC)method to determine the content of the four major effective ingredient of TSG in thesame time. Establish the quality standards of TSG. TSG is stable under dry conditions at roomtemperature, protected from light...