| Chlorine dioxide has been very widely used in real life, for it is environmental-friendlyand its efficient bactericidal properties. In recent years sustained-release solid dosage ofchlorine dioxide has been initially developed, as an emerging field of research, such aschlorine dioxide gel powder, chlorine dioxide reaction cartridge, chlorine dioxide capsules,tablets chlorine dioxide. Fruits and vegetables picked can be stored in cold storage, but duringlong-distance transport, they will be easy to rot, influenced by the environment. For thisreason, the development of preservation technology during storage and transportation of freshfruits and vegetables become particularly important. The main work is as follows:（1）The structure of chlorine dioxide film was designed. The film was consist of twoparts, A and B membranes with nonwoven material of size3×5cm, and the size ofantibacterial space was4.77L. A film was loaded with the activator component coated by β-cyclodextrin, and drug loading was0.21g. while B film was loaded with sodium chloritecoated by polyvinyl alcohol, and drug loading was0.14g. Between A and B membranescontrolled release membrane was added.（2）The activation effect of different activator systems on chlorine dioxide parentmaterial was researched, and ultimately the best formulation activator system was determined.Activator was composed of acidifier A and acidifier B, wherein the mass ratio of the acidifierA and acidifier B was1:2, the mass ratio of activator and sodium chlorite was1:1, and themass ratio of promoting release agent and activator was2:3. （3）The preparation of β-cyclodextrin-activator inclusion. With β-cyclodextrin as themain inclusion and activator as the object, inclusion experiments were carried out by usingsaturated aqueous method and ultrasonic method to explore the characteristics of β-cyclodextrin-activator inclusion complex. During the experiment using saturated aqueousmethod, factors which have impact on forming inclusion complexes were studied, such asmass ratio of the components, stirring speed, reaction time, temperature, and the orthogonalexperiment was conducted to optimize the process of inclusion. In the ultrasonic test,according to the characteristics of the ultrasonic dispersion, the inclusion reaction waspromoted by taking use of ultrasound effect. Finally, infrared spectroscopy and opticalmicroscopy were used to characterize inclusion complexes. The results showed that insaturated aqueous method test, when the mass ratio of β-CD and activator was1:3, reactiontemperature30℃, stirring speed350r/min, reaction time3h, the result was best; comparedwith saturated aqueous method ultrasonic method was easier, but the inclusion complexesobtained was few with serious loss of drugs; through IR spectroscopy and optical microscopyanalysis, the fact that substances after inclusion were polyhedral translucent crystal form,containing opaque lumps, showed activator had been encased by β-CD.（4）Discuss the effect of environmental humidity, promoting release agent, andmoisture permeability of controlled-release film on the stability of chlorine dioxide film. Theresults showed that when the environment humidity changed from55%±2%to95%±2%, theeffective release days at ambient humidity of85%±2%, was the longest, up to11d, totalemission was17.185mg, and effective release rate was35.9%. Then environment humiditywas fixed at85%±2%, and the controlled-release films with moisture permeability of68%±20%and33%±20%were added between film A and film B. The results showed that the controlled release film with moisture permeability of33%±20%could not only adjust thedaily release amount to between0.15~1.5mg, but also extend the effective release days up to17days, significantly better than plastic wrap with moisture permeability of68%±20%.However, the effective release rate was lower, only21.5%. On the basis, it can increase theeffective release rate to25%to add the promoting release agent.（5）Discuss release characteristics and mechanism of sustained-release chlorinedioxide film and establish release kinetics model which can be applied to the actual releaselaw. Release rules and mechanistic models of solid chlorine dioxide show that the reaction gothrough two stages, that is the release of chlorine dioxide increasing stage and decreasingstage with reaction time. Two stages both meet the kinetics, and kinetic equations arey=0.665-0.064x+0.032x2and y=1.49-0.08x，R~2=0.867... |
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