Clinical Research Of Cancer Related Anemia In Malignant Solid Tumor

Objective: Through case viewing, sum up the overall incidence and treatment ofmalignant solid tumor related anemia in this area; to investigate influence factors ofoccurrence and prognosis of gastrointestinal cancer-related anemia, and to provide theoreticalreference to clinical treatment and prognosis estimation.Methods: The research objects is2324cases malignant solid tumor patients in GeneralHospital Of Ningxia Medical University from January2009to December2009,the patientsmust be meet the conditions of histopathological diagnosis and complete medical records.First of all, sum up the incidence, clinical characteristics of anemia in patients with newlydiagnosed malignant solid tumor pathogenesis, overall incidence of treatment-related anemiaand anemia treatment; secondly, filter out of668cases from2,324cases of malignant tumorin gastrointestinal tract, Analysising tumor-related anemia influential factors among gender,age, ethnicity, weight loss, serum albumin level, course of disease, bleeding, complication,tumor location,degree of differentiation, the stage of clinical pathology and treatmentmethods; Kaplan-Meier analysis was used to analysis the relevance between anemiadegree,Corrects the anemia and the patient survives.Results:1. The first diagnoses anemia incidence of2324cases is17.00%,treatment-related anemia incidence is48.92%, overall anemia incidence is53.40%; TheGraduation of anemia mainly is the first grade(78.00%) and the second grade (20.31%); mostof the anemia type is normal cellularity (81.14%).2. In the patients of first diagnoses anemia,male account for48.61%, female account for51.39%; aged and later period patients is theanemia peak crowds (account for42.78%,46.08%); the anemia incidence highest is the digesting system tumor, accounts for56.96%(225/395); the second and third grade anemiaconcentrates in gastro-intestinal tract malignant tumor71.72%（71/99）, in the smallcellularity anemia, the stomach cancer (accounts for48.57%) and colon cancer (accounts for25.71%) constitution to be quite high; Along with malignant solid tumor clinical-pathologystages increasing, the anemia incidence gradually rises,the graduation of anemia mainly is thefirst and second grade;the third and fourth grade anemia extremely occurred in III and IVstage patients; the anti tumor treatment (surgery, chemotherapy and radiotherapy) willincrease and aggravate the occurrence of anemia, especially in surgery (to account for44.68%); In1241cases of gastro-intestinal tract malignant tumor relevant anemia patientsaccept the blood transfusion to treat168people (to account for13.54%), EPO treats10people (to account for0.81%), the iron tonic treats23people (to account for1.85%), namelythe anemia treatment rate is16.20%(201/1241).3. The incidence of stomach cancer relatedanemia is71.13%, occur in the gastric antrum; The incidence of colon cancer related anemiais68.99%, occurred in the right hemicolon.4. The univariate analyses showed that thepatients sex, nationality,weight loss, the analbuminemia, bleeding, tumor differentiationdegree,clinical staging and anti tumor treatment related with the stomach cancer relatedanemia, the difference has the statistical significance (P<0.05); the patients sex, weight loss,the analbuminemia, bleeding, tumor location, tumor diameter and anti tumor treatmentrelated with the colon cancer related anemia, the difference has the statistical significance(P<0.05).Multivariate logistic regression analyses revealed that Han, the analbuminemia,advanced stage and anti tumor treatment are the related factors of the stomach cancer relatedanemia; the female, the analbuminemia and anti tumor treatment are the related factors of thecolon cancer related anemia.5. In469cases of gastro-intestinal tract malignant tumorrelevant anemia patients accept the blood transfusion to treat112people (to account for23.88%), EPO treats3people (to account for0.64%), the iron tonic treats3people (toaccount for0.64%), namely the anemia treatment rate is25.16%(118/469).6. In gastro-intestinal tract malignant tumor patient, the anemia degree is heavier, the life is shorter,the difference has the statistical significance (χ2=12.555, P=0.006<0.05; χ2=6.283,P=0.043<0.05), survival difference between correct the anemia group and not correct theanemia group has non-statistical significance (χ2=1.076, P=0.300>0.05).Conclusion:1.In this area, the incidence of malignant solid tumor related anemia is high,reaches more than50%, the middle，aged and later period patients to account for the greatproportion, the proportion between male and female is almost the same. The anti tumortreatment (surgery, chemotherapy and radiotherapy) will increase and aggravate theoccurrence of anemia.2. The highest proportion of third degree anemia is digesting systemtumor patients, especially in stomach cancer and colon cancer. The predisposing factors ofGastric cancer related anemia are the Han, the low albuminemia, later period and anti-tumortherapy; susceptible population of colorectal cancer related anemia is female,the lowalbuminemia and anti-tumor therapy.3.Patient survives is closely related to the Classificationof gastro-intestinal tract malignant tumor relevant anemia.4.The treatment rate of malignantsolid tumor related anemia is low in this area,corrects the anemia method to be unitary, isprimarily for transfusing blood.