| ObjectiveTo investigate the effect of isotonic magnesium sulfate aerosol inhalation on thecardiovascular response, intraoperative airway pressure and postoperative sore throat for thepatients undergoing general anaesthesia and intubation, to explorethe primary mechanism ofthe effect.MethodOne hundred patients with the thyorid neoplasm were randomly divided into twogroups: isotonic magnesium sulfate group(group M,n=50)and saline group（group C，n=50）.Compare the changes of hemodynamic parameters while intubation, mean airway-pressure(Pmean）and peak airway presure(Ppeak) during the maintenance of anesthesia andthe visual analogue scale of postoperative sore throat(VAS) between the two groups.ResultsCompare group M to group C:①The basal BP and HR had no significant differencecompare to the anesthesia induction was done, while the highest BP and HR were lower thanthat of group C during the time from the beginning to finishing of intubation, which had sta-tistic difference(P<0.05);②Pmean and Ppeak of the patients in the group M during main-tenance of anesthesia were significantly lower (P <0.05) that of group C.③the VAS score ofpostoperative sore throatin two groups in30min had no significant difference (P>0.05)， theVAS of postoperative sore throat in2-24hours were statistically difference(P <0.05).ResultIsotonic magnesium sulfate oxygen inhalation can effectively suppress the stress re-sponse caused by intubation, hemodynamics were more stable after intubationand can effec-tively reduce airway pressure and alleviate postoperative sore throat during the maintenanceof anesthesia in patients,which had the clinical promotional value. |
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