Changes Of Electroencephalogram In Children With Partial Seizures Treated By Carbamazepine And Levetiracetam As Monotherapy

Objective:to observe the changes of electroencephalogram(EEG) in children with partial seizures treated with Carbamazepine or Levetiracetam.Methods:Choose80children diagnosed with partial seizures and randomly divided into2groups, every group40children. Carbamazepine and Levetiracetam are used respectively for the two groups. And their EEGs are examined before therapy and every3months after therapy and the attention is paid to the changes.Results:clinical controls over seizures are not significantly different between the two groups(P=0.68), but the epileptic discharges is obviously different(P=0.001):for the CBZ group, the epileptic discharges in7children disappear,7decrease more than50%,11decrease25%-49%,8show no changes in epileptic discharges and7increase. While for the LEV group, the epileptic discharges in21children disappear,7decrease more than50%,6decrease25%-49%,3show no changes in epileptic discharges and3increase.Conclusion:LEV can significantly decrease the epileptic discharges on EEG. As a new anti-epileptic drug, LEV has a promising future in clinical use for treating children with partial seizures.