In Patients Undergoing Lung Resection For Non-small Cell Lung Cancer, Is Lymph Node Dissection Or Sampling Superior?

Purpose Analysis of the effection of the two opreational methods betweenmediastinal lymph node sampling and system dissection with the postoperatively5-yearsurvival rate, pathologically precise staging, postoperatively local recurrence, distantmetastasis and complications in the surgical treatment of non-small cell lung cancer.Method Retrieval of Medline (1966-2011), Embus (1980-2011), SCI (1974-2011),the Comchrane Library (1998-2011), Chinese biomedical literature database(1989-2011), Chinese science and Technology Periodical Full-text Database(1989-2011), China Journal Full-text Database (1994-2011) by means of computer, andmanual retrieval of magazine of lung cancer, cancer, Chinese Journal of lung cancer,tumor, cancer (age to1995-2011) in library. Systematically collection and evaluation ofrelevant information, analysis data by Rev Man5.0, and result in merged OR values and95%CI. Totally cover11research literature articles(consist of6B levels and5C levels),a total of4103cases of object of study (consist of2056cases of dissection group and2047cases of sampling group).Result:1. There is no statistically significance for two kinds of operation mode on5years survival rate after non-small cell lung cancer operation in stage I.2. There isstatistically significance for two kinds of operation mode on5years survival rate afternon-small cell lung cancer operation in stage II-IIIa. The advantage of death ofsampling is1.8times higher than that of dissection group (OR=1.80,95%CI(1.19,2.72))even if the analystic result of sensitivity is not stable regardless of the most authoritativeliterature, the advantage of death still tends to the side of sampling group.3. Comparedwith sampling group of the two kinds of operation mode, Multiple N2detection rate increased to OR=4.45,95%CI(2.95，6.71)in the dissection group after non-small celllung cancer operation,4. There is no statistically significance for two kinds of operationmode on difference on postoperatively local recurrence and distant metastasisConclusion:1.There is no difference of5-years survival rate between mediastinallymph node sampling and dissection on I stage non-small cell lung cancer patient, buton the II-IIIa stage non-small cell lung cancer there is. Compared with sampling group,the advantages of death was decreased and5years survival rate was increased inLymph node dissection group.2. In terms of Multiple N2detection rate and accuratestaging after operation, mediastinal lymph node dissection type could increase in thenumber of group N2detection rate and make pathological staging most accurate.3.Thereis no statistically significance for postoperative local recurrence and distant metastasisof non-small cell lung cancer patients on the two kinds of operation mode ofmediastinal lymph node dissection and sampling.