ObjectiveTo evaluate the role of ultrasound in rheumatic diseases, analysising the correlation between Disease Activity Score (DAS28) and musculoskeletal ultrasound score in patients with active rheumatoid at the baseline. Establish a simplified project of ultrasound in monitoring disease activity in rheumatoid arthritis, and verify the validity of the project at the baseline and after DMARDs treatment3months.MethodsA total of50patients with active RA who who have didn’t started the DMARDs agent were prospectively recruited in the Second hospital of Shanxi Medical university. The patients underwent clinical and laboratory assessment and blinded musculoskeletal ultrasound examination at baseline and3months. US count and index for synovitis and CDU signal were obtained. A process of data reduction based on the frequency of involvement of synovial sites by both synovitis and CDU signal was conducted. Construct and discriminant validity of a simplified ultrasound assessment was investigated.Results1.There was a significant correlation between US and DAS28in the test before DMARDs treatment (r=0.439P<0.05). 2.According to the frequency of each joint involvement before treatment, set a contains10joints (wrist joint, third,4and second proximal interphalangeal joint, metacarpophalangeal joint and double knee joint) ultrasonography scheme is simplified, the simplified solution before and after the treatment in the clear correlation between mean and ultrasonic examination consists of28joint the integral and DAS28(before r=0.618P<0.05; after r=0.618P<0/05)3. The simplified solution contain only CDU score also has a clear correlation between DAS28at the the baseline and after DMARDs treatment3months (before r=0.355P<0.05, after r=0.786P<0.05).Conclusions1. As a non-invasive, rapid examination method,ultrasound provide more qualitative, quantitative information of inflammatory in patients with rheumatoid arthritis.2.A US simplified assessment including10joints color Doppler ultrasound may be a valid, feasible method for multicenter monitoring of therapeutic response to biologic agents.3.CDU as an objective reflection of perfusion can prompt inflammation of RA disease activity, also be a simple indicators for monitoring patients disease activity with RA... |