The Relationship Between Plasma Homocysteine With Mild Cognitive Impairment And Alzheimer’s Disease In Rural Area Of Lvliang

Backgorund:With the rapid increase in life expectancy in the population, dementia is becoming one of the important healthy problems. Alzheimer’s disease (AD) is a progressive degenerative disease of the central nervous system. Its clinical manife-stations are memory and cognitive impairments, speech disorders and psychomotor abnormalities, et al. Mild cognitive impairment(MCI) which is becoming a research hotspot refers to the transitional clinical state between normal aging and dementia or AD. Previous studies relating homocysteine(Hcy) levels with the risk of AD or MCI were inconsistent. Some studies reported associations between elevated homocysteine levels and an increased risk of cognitive impairment. It is valuable to further study the relationship between homocysteine with AD and MCI for prevention and treatment of AD.Objective:To explore the relationship between homocysteine with mild cognitive impairment and Alzheimer’s disease in the rural area of Lvliang city, Shanxi province. The relationship between AD and MCI with folic acid and vitamin B12is also studied to provide the basis for the prevention and treatment guidance of AD.Methods:Participants who are older than55years old were enrolled in a cross-sectional survey in three towns of Lvliang, Shanxi province. We screened135AD patients and157MCI patients in6452participants. The trial was based on case control study. We selected63AD patients and95MCI patients with blood samples, and randomly selected control group of90patients. Plasma Hcy concentrations were assayed by fluorescence polarization immunoassay technology. Plasma concen- trations of folate and vitaminB12were assayed by microparticle enzyme immun-oassay. All data were analyzed by SPSS17.0.Results:1. The mean plasma Hey concentration in AD, MCI and control group were26.6±19.94μmol/L,27.2±19.80μmol/L and19.7±14.42μmol/L. The deviations of plasma Hey concentration were significant among three groups (p<0.05). The deviations of plasma Hey concentration were significant.among AD and control group, MCI and control group(p<0.05), and were not significant among AD and MCI group (p>0.05).2. In AD, MCI and control group, the serum folic acid concentration were8.85±4.87ng/mL,9.60±5.03ng/mL and10.37±5.58ng/mL, and the serum vitamin B12were154.52±89.08pg/mL,147.46±81.07pg/mL and155.18±83.92pg/mL respe-ctively. The deviations of serum folic acid and vitamin B12concentration were not significant among the three groups (P>0.05).Conclusions:1.The Hey concentration in AD and MCI patients were higher than in control group in rural area of Lvliang, Shanxi province.2.High Hey levels may be a risk factor for AD and MCI in rural of rural area of Lvliang, Shanxi province.3.The folic acid and vitamin B12concentration in AD and MCI patients may be not lower in control group in rural area of Lvliang, Shanxi province.