Clinical Observation On Effects Of Xuebijing Injection On High Mobility Group Box-1Protein Of Patients With Septic Shock

ObjectiveTo investigate the expressing levels of xuebijing injection on high mobility group box-1protein(HMGB1) of patients with septic shock, and to explore the role of HMGB1in pathogenesis of sepsis and sepsis severity and prognosis.Methods48cases observed between November2010to November2011, First Affiliated Hospital of Zhengzhou University, ICU patients with septic shock. Randomly divided into treatment group (24cases) and control group (24cases).Both groups were given the traditional Western methods of treatment, the treatment group, plus Xuebijing injection on the basis of the above-mentioned method.Admission to the ICU treatment (tO) and after admission to the ICU for3days (t3),5d (t5),7d (t7) were collected at two groups of patients vital signs (including body temperature, respiration, pulseblood pressure), blood, liver function, kidney function, blood coagulation, and the APACHEII score.At the same time pumping blood to check C-reactive procalcitonin (PCT), lactic acid of HMGB1. Track the outcome of the patients, and patients were divided into the survival group and death group and28days mortality.The analysis of two groups of patients with septic shock the level of expression of HMGB1. Explore the relationship between HMGB1and sepsis severity of disease and prognosis. ResultsTreatment group and control group into the ICU, vital signs, blood, liver function, kidney function, blood coagulation, immune function, and APACHE II score, PCT, lactic acid, HMGB1were not statistically significant (P>0.05). Before treatment in patients with septic shock plasma HMGB1concentration and APACHE II score, procalcitonin, and blood lactate levels of positive correlation.Treatment,3d, compared to two APACHEII score and burglary were significantly decreased (P<0.05), treatment group APACHEII score decreased more significantly (P<0.01); HMGBl with the burglary of the control group compared to non-significantly decreased (P>0.05), treatment group, HMGBl significantly decreased on5th day, and the same point in the treatment group compared with the control group, significant difference of HMGBl decreased significantly (P<0.005). Tracking patient outcomes (mortality28days)28days of the treatment group and control group mortality rates were33.3%and50%group, the difference being statistically significant (P<0.05). Changes in the dynamic monitoring of HMGB1, with disease progression, survival group of HMGB1with the condition improved significantly decreased, while three days after the death of the group HMGB1burglary have significantly higher, and sustained at a high level. Patients with septic shock in1,3and5days of admission to the ICU of HMGB1receiver operating characteristic (ROC) area under the curve were:0.539[95%CI (0.355-0.724), P=0.678];.882[95%CI (0.780-0.985), P<0.01];0.982[95%CI (0.000-1.000), P<0.000].ConclusionsDynamic detection of plasma HMGB1concentration can be used as septic shock, severity and prognosis of an evaluation index. On the basis of Western medicine treatment can reduce the mortality of patients with the Xuebijing injection The mechanism may reduce the expression of HNGB1.