The Study On The Changes Of Lung Function With HD CT Scanning In Smokers And COPD Patients

Objective: To study the value of lung function software in analysis the lung functionand the small airway changes in the patients who are chronic obstructive pulmonarydiseases (COPD) and smokers by using64-row helical CT analysis software.Materials and Methods： Nineteen COPD patients and27healthy volunteerswere joined into our study(23men and23women, average age were57.76±14.39years), who were all excluded other diseases, such as lung inflammation, chest surgery,chest tumor, chest tuberculosis and so on. All the subjects accept CT examination at theend of the inspiration and expiration. And using CT pulmonary functional quantitysoftware to analyze all images and calculate CT pulmonary function parameters, such asdensity, the lung CT volume of the end of inspiration and expiration volume, andmeasuring the narrow diameter, the largest diameter, the wall area, the thickness of themaximum and minimum values, and thickness of the average of5levels of bronchialairway. And to analysis the difference values between the COPD patients and healthyvolunteers, the differences between smokers and nonsmokers, passive smokers andnon-smokers of all volunteers, and the differences between smokers, passive smokersand non-smokers of healthy volunteers. Using SPSS16.0statistical software for analysis,with P<0.05for significant differences.Results1. COPD group and non-COPD group①The emphysema percentagecomposition of COPD group was6.106±7.147%,and non-COPD group was3.250±3.671%, the two groups have significant differences(P=0.028). And emphysemapercentage composition of COPD group in the upper and middle lobes of right lungwere higher than left lung.(p=0.000,0.002,).But there have no significant differencesin lower lobes of lung（P=0.347，0.511）.②The emphysema percentage composition ofCOPD expiration phase was better than the inspiration phase (p=0.019,0.028).③The average thickness of5th levels of bronchial airway of COPD group（1.295±0.399mm）were higher than the healthy grou（p1.270±0.230mm）(p=0.019).And the wall area ofCOPD group higher than the healthy group.2. Smoker group, nonsmoking group and passive smoking group of allvolunteers①The emphysema percentage composition of the smoker group, passivegroup and nonsmoking smoking group were6.806±7.525%,3,141±4.647%,3.182±2.479%,and the smoker group higher than passive smoking and nonsmokinggroup（P=0.035、0.001）.②The average thickness of bronchial airway of smoking group（1.462±0.342mm）were higher than the nonsmoking group（1.150±0.213mm）(p=0.015). The averageand minimum thickness of bronchial airway of smoking group and passive smokinggroup have no significant differences (p=0.100,0.015),only maximum thicknesshigher than passive smoking group(P=0.031).③With the increase of smoking the maximumdiameter,wall area and wall thickness increase gradually.3．Smoker group, nonsmoking group and passive smoking group in healthperson①The emphysema percentage composition of the smoker group, passivesmoking group and nonsmoking group were2.702±1.894%,3.607±5.447%,3.277±2.549%,have no significant differences（P﹥0.05）.②The average thickness of bronchial airway of smoking group（1.343±0.270mm）higher than nonsmoking group（1.240±0.117mm）（p=0.047）.③The wallarea ofnonsmoking group, passive smoking group and smokeing group were7.320±3.249mm,13.290±3.370mm,15.249±4.119mm,and the wall areas of the three group havepositive correlation(r=0.669,P=0.000).Conclusions1.This study confirm the inspiration and expiration examination and the CT lungfunction software of HDCT can provide more values about lung function and structurefor COPD patients.2.The lung function software of HDCT are very useful in founding the changesabout wall area and thickness of bronchial airway of smoking group and passivesmoking group. In order to predict and evaluation the potential changes of lung function.And CT lung function is expected to become an important imaging method of testingthe effects of smoking on lung function.